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Immunosuppressive protocols after cryopreserved aortal allotransplantation in rats.
Špunda, Rudolf ; Špaček, Miroslav (advisor) ; Moláček, Jiří (referee) ; Rohn, Vilém (referee)
The aim of our study was to simulate in rats all aspects and techniques used in our new clinical program of cryopreserved alloarterial transplantation and investigate the influence of two immunosuppressive protocols with tacrolimus on acute rejection of these allografts. Cryopreserved abdominal aortic grafts were transplanted between Brown-Norway and Lewis rats. Tacrolimus (0,2 mg/kg daily) was administered from day 1 to day 30 (TAC1) or from day 7 to day 30 (TAC7), respectively. No immunosuppressed isogeneic (ISO) and allogeneic (ALO) rats combination served as control. Aortal wall destruction and infiltration by immunocompetent cells (MHC II+ cells of recipient origin) was studied on day 30 after transplantation. Flow cytometry was used for the analysis of day 30 sera for the presence of donor specific anti-MHC class I and II antibodies. The aortal allografts in both immunosuppressed groups showed regular morphology of aortal wall with no depositions of immunoglobulin G on day 30. The adventitial infiltration of non-immunosuppressed aortal allografts by MHC class II positive cells of recipient origin was significantly higher (ALO 20,7±6,7 cells, P <0,001) compared to both immunosuppressed groups (TAC1 5,9±5,5 cells, TAC7 6,1±5,1 cells). Anti-MHC antibodies class I and II level in peripheral blood...
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Apartment house with barrier-free apartments
Špaček, Miroslav ; Hnízdilová, Aneta Aya (referee) ; Utíkalová, Ivana (advisor)
The topic of bachelor´s thesis is design four storey apartment house with barrier-free apartments. The building is four storey, roofed hipped roof. The fourth floor is residential attic. The building is located on plot of number 3800/32 in the village Velke Mezirici, cadastral area Velke Mezirici. The vertical constructions are designed from aerated concrete block Ytong and there are insulated with contact insulation systém ETICS. Horizontal constructions are designed large format precast floor slabs Ytong. The roofing is done using timber roof truss. Part of the design is thermal assessment, accustic assessment and fire safety assessment.
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Pre-feasibility study of commercial LNG production in the Czech Republic
Obergruber, Michal ; Špaček, Miroslav (advisor) ; Hönig, Vladimír (referee)
Due to the shortage of oil and the current environmental pollution problems, there is a growing need for alternative energy sources. Compressed or liquefied natural gas is shown as a prospective fuel. For LNG, consumption of 100 million Nm3/year is predicted by 2030. This work aims to prepare a pre-feasibility study for the production of LNG in the Czech Republic, which would be able to cover this predicted demand. The economic concept of the chemistry-engineering approach provides comprehensive information about the topic. The results show that the planned plant will unfortunately not be profitable, as compared to the current LNG price imported to European seaports, the price of the produced product in the factory considered would be roughly twice as high.
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Nutritional status in patients suffering from deep sternal wound infection
Štroblová, Petra ; Špaček, Miroslav (advisor) ; Zlatohlávek, Lukáš (referee)
Introduction: The procedure of longitudinal median sternotomy is the most commonly used approach in cardiac surgery with the necessary complex postoperative treatment. A multifactorial approach is particularly important to prevent later complications, which can be very serious or fatal. The theoretical part of the thesis is not just about the risk factors that may interfere with the healing process but also about nutritional measures that could reduce the risk or completely prevent the profound dehiscence of the sternotomic wound. Methodology: The research method consisted of a retrospective analysis of the risk factors of deep sternal dehiscence in 22 patients who underwent cardiac surgery using the technique of longitudinal median sternotomy over a ten-year interval. 11 patients with sternal healing disorder were selected and included in group 1. Subsequently, an additional 11 patients were selected without sternal dehiscence. These patients were selected in such a way that their characteristics corresponded to the characteristics of patients of the first group in terms of statistical evaluation and comparison of both groups (type of exercise, length of operation, use of extracorporeal circulation, LIMA / BIMA, etc.). In the selection of patients in the control group 2, the laboratory nutrition...
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THE ETHICAL PROBLEMS OF HOME HELP AND POSSIBILITES OF TREIR SOLUTIONS ACCORDING TO BASIC ETHICAL ATTITUDES
Špaček, Miroslav ; Keřkovský, Pavel (advisor) ; Fischer, Ondřej (referee)
This thesis deals with the theme of ethical problems and dilemmas we can meet when providing day care. The basic ethical norms for solving these problems are presented in the first part. Chosen ethical problems and dilemmas of various cases of day care practice are described in the next part. The attitude of the Law of Social Services as the basic legal norm for providing day care service in the Czech Republic follows each of the cases. Afterwards, each case is considered in the relation to the Ethical Code of social workers in the Czech Republic. This code contains ethical principles and the rules of ethical behaviour of a social worker towards the client, colleagues, employers and society. Then the care is judged from the point of view of some ethical theories. Next, the real solving of the case and its assessment from the point of view of the ethical norms of treatment is presented. The results of solving concrete situations are compared according to different ethical theories in the final part. This thesis does not include a questionnaire because of the individual attitude to the client and the theoretical orientation of this work. KEY WORDS The Law Of Social Services, The Ethical Code Of The Social Workers In The Czech Republic, day care, social worker, health visitor, client, the contract of...
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Social Services for Homeless in Pardubice
Špaček, Miroslav ; Dočkal, Jan (advisor) ; Dočkal, Jan (referee)
There is actual conditon of providing social services for homeless people in Pardubice in this graduation work, confront with the needs of these people that are expressed in the questionnaire. Social work and its distinction according the structure of service purpose in the institutions of social services for homeless people in Pardubice is described very properly in this graduation work. There is sollution of disproportion between offer and demand for individual social instituons in Pardubice suggested in the end of this graduation work. The main change would be in the origin of new institutions such as Lodging house for women, Subliminal institution for homeless people, Social and sanitary institution for homeless people and Housing for seniors and deseased homeless people in the end of this graduation work. Powered by TCPDF (www.tcpdf.org)
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Diagnosing vascular prosthesis infection by means of the FDG-PET/CT
Špaček, Miroslav ; Bělohlávek, Otakar (advisor) ; Vojáček, Jan (referee) ; Gregor, Zdeněk (referee)
Introduction: Vascular prosthesis infection (VPI) is a life-threatening complication in 0.5- 5% of cases. Early and reliable diagnosis is a necessity for adequate treatment. Computed tomography (CT) is the gold standard diagnostic method used world-wide with excellent results, but in cases of advanced graft infection. Low grade infections in non-acute patients are a diagnostic challenge requiring a new method with good diagnostic accuracy. The aim of this work is to define the accuracy of 18 F-FDG PET/CT in these settings and to identify essential parameters of its evaluation. Material and Methods: Seventy-six consecutive patients with total of 96 vascular prosthetic grafts in which infection was suspected underwent PET/CT examination prospectively. PET/CT scans were analysed in terms of presence and intensity of focal and diffuse FDG uptake, presence of anastomotic pseudoaneurysm, irregular boundary of infiltration, combination of these, and uptake ratio between graft and blood background. Also, other parameters like white blood cell count, C-reactive protein, and microbiological cultures were tested. The final diagnosis (gold standard) was based on operative/histopathological finding or >6 months clinical follow up. Results: In our series the prevalence of VPI was 57.3 % (55/96 prostheses). Among various...
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Innovations in the Banking sector
Khachukaeva, Bella ; Špaček, Miroslav (advisor) ; Mareš, Jan (referee)
The aim of this thesis is to propose improvements in the selected banking process. This thesis consists of a theoretical and a practical part. The theoretical part is devoted to the traditional and banking approaches to innovations. The definition of innovations, classification, sources, models of innovation process, barriers to innovations are defined in the theoretical part. The practical part is devoted to the analysis of the process and a proposal of the innovation model of the process.
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