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A study of directly compressible tableting materials and tablets with chitosan.
Fleglová, Eliška ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical Technology Student Eliška Fleglová Consultant doc. PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis A study of directly compressible tableting materials and tablets with chitosan. This thesis deals with the study of compressibility of directly compressible tableting materials with chitosan, their lubricant sensitivity and tensile strength of tablets. Other components of tableting materials are sodium alginate in a concentrations of 30, 40 and 50 %, or the combinations of sodium alginate and hypromellose 15M in the ratio of 1: 1 in the same concentrations. Magnesium stearate in a concentration of 1 % is used as a lubricant. Indomethacin in a concentration of 20 % is used as a model drug. Tablets without lubricant and without drug are compressed by compression forces 4, 4,5 and 5 kN, tablets with lubricant and with drug by compression force 4 kN using the material testing equipment T1- FRO 50 Zwick/Roell. The compressibility is evaluated by the energy profile of the compression process, sensitivity to lubricants by values lubricant sensitivity ratio. The total energy of compression increases with the compression force. It is the highest for chitosan alone. The addition of retardants decreases its values. The...
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Influence of fillers and disintegrants type on properties of tablets with high dose drug.
Tranová, Thao ; Mužíková, Jitka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Consultant: doc. PharmDr. Jitka Mužíková, Ph.D. Student: Thao Tranová Title of Thesis: Influence of fillers' and disintegrants' type on properties of tablets with high dose drug The work engages in the study of fillers' and extragranular superdisintegrants' influence on properties of tablets with high dose drug. Two types of granulate with lactose or microcrystalline cellulose were produced in high shear granulator. Eleven tablets groups with different type and amount of superdisintegrants were prepared from the granulates. Tablets contained 2 %, 3.7 %, 5.4 % of sodium croscarmellose or 2 % and 5.4 % of crospovidone. The tested parameters of tablets were friability, hardness, disintegration time and density. Accelerated stability studies lasting 6 months at temperature of 40 řC and relative humidity 75 % were done. The tablets were evaluated after 1.5, 3 and 6 months. All tablets had adequate friability, hardness, disintegration and density at T0. Increasing concentration of superdisintegrant decreased disintegration time. Tablets containing microcrystalline cellulose and sodium croscarmellose disintegrated faster than tablets containing lactose or crospovidone. Tablets with sodium croscarmellose had...
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The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets.
Rumlerová, Lenka ; Ondrejček, Pavel (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Department of Pharmaceutical Technology Consultant: PharmDr. Pavel Ondrejček, Ph.D Student: Lenka Rumlerová Title of Thesis: The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets. This thesis deals with influence of rice extract, as a new kind of glidant on compressibility of microcrystalline celulose as a model filler. Furthermore it evaluates the impact of rice extract on tablet properties. Effects of rice extract were compared with two standard glidants - magnesium stearate and colloidal silicon dioxide. As first the influence of diferent glidants concetrations on flow properties of mixtures were assesed. Tablets were compresed using three different compression forces. A force- displacement record was used to evaluate the compressibility of microcrystalline cellulose and its mixtures with glidants. Subsequently, the properties of tablets were evaluated. The radial strenght, abrasion, and tablet disintegration time were measured. The results revealed that the rice extract has the least effect on mixtures flow poperties. However, all mixtures showed a statistically significant improvement in flowability. When using a 1 % rice extract, the flow properties of the...
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A study of tableting materials and tablets with the combination of microcrystalline celulose and mannitol for orally disintegrating tablets.
Novotná, Andrea ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Andrea Novotná Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of tableting materials and tablets with the combination of microcrystalline cellulose and mannitol for orally disintegrating tablets This thesis compares co-processed dry binder Avicel® HFE-102 containing 90 % microcrystalline cellulose and 10 % mannitol with a physical mixture of related dry binders, microcrystalline cellulose (Avicel® PH-102) and mannitol (Pearlitol® 100SD) in the ratio of 9:1. Flow properties, compressibility, lubricant sensitivity, tensile strength and disintegration time of tablets are evaluated. Compressibility is evaluated by means of the energy profile of compression process, and lubricant sensitivity by means of the lubricant sensitivity ratio. The results are also compared with the microcrystalline cellulose for direct compression Avicel® PH-102 alone. The flow properties of the co-processed dry binder Avicel® HFE-102 alone and the physical mixture were comparable. Avicel® HFE-102 showed higher values of the energy of plastic deformation, tensile strength of tablets, and a markedly lower lubricant sensitivity than the physical mixture of dry binders. Tablets with the...
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A study of the coprocessed dry binder with mannitol, lactose, dextrose and crospovidone for orally disintegrating tablets.
Bímová, Daniela ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Daniela Bímová Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of the coprocessed dry binder with mannitol, lactose, dextrose and crospovidone for orally disintegrating tablets. This work evaluates and compares directly compressible tableting materials and tablets with Disintequik® ODT, which is used for the production of orodispersible tablets. The effect of three lubricants in two concentrations (0.5 and 1 %) on the properties of tableting materials and tablets is evaluated. Tested lubricants are magnesium stearate, calcium stearate and sodium stearyl fumarate. The tested parameters are flow properties, further compressibility, ejection force, tensile strength and disintegration time of tablets in the dependence on compression force. The compressibility is evaluated by the energy profile of the compression process. The lubricants improved the flowability of Disintequik® ODT and the best values were in the case of calcium stearate. The total energy of the compression increased with the compression force and the highest values were seen in the tableting materials with magnesium stearate. The values of plasticity decreased with the compression force. The ejection...
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Effect of compaction pressure on the compressibility of Neusilin US2 and polyethylene glycol mixtures
Svobodová, Aneta ; Vraníková, Barbora (advisor) ; Mužíková, Jitka (referee)
1 Abstract Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Candidate: Aneta Svobodová Supervisior: PharmDr. Barbora Vraníková, Ph.D. Title of Diploma Thesis: Effect of compaction pressure on the compressibility of Neusilin US2 and polyethylene glycol mixtures The liquisolid systems are modern preparations, that are capable to release a poorly soluble drug from the dosage form faster and thus increase its biovailability. The main principle of their preparation is conversion of the drug in the liquid state to a dry, non-adhesive powder with suitable flow properties allowing the subsequent formation of tablets or capsules. The aim of this diploma thesis was to determine the effect of compaction pressure on the tablets parameters (mass uniformity, height and diameter, hardness, friability, disintegration time and pycnometric density) prepared from mixtures containing different ratio of Neusilin US2 and polyethylene glycol 200. It was found that the best parameters were observed in tablets compressed using higher forces (2.0 and 2.5 kN). Compression forces of 0.5 and 1.0 kN led to the preparation of compacts with insufficient mechanical resistence. Mixture containing 60 % PEG 200 was selected as the best one as it implied the highest volues hardness...
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Homogenization of powder blends using a Turbula mixer.
Litošová, Martina ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
1 Abstract Charles University, Faculty of Pharmacy in Hradci Králové Department of: Department of Pharmaceutical Technology Supervisor: Doc. PharmDr. Zdeňka Šklubalová, Ph. D. Consultant PharmDr. Karel Palát, CSc., Mgr. Žofie Trpělková Student: Martina Litošová Title of Thesis: Homogenization of powder blends using a Turbula mixer. In this experimental work, the influencing of the homogeneity of the powder mixture of acetylsalicylic acid (ASA) and microcrystalline cellulose (Avicel PH102) due to the rotational speed of the mixing container in a range of 23−101 rpm, and the mixing time was studied using the Turbula shaker mixer. Within time interval 2-62 minutes, the content of ASA in samples was measured by near-infrared spectrometry. The expression of standard deviation was used to evaluate the homogeneity of samples. The best results were detected at a rotational speed of 34 rpm within time interval of 14−30 min.
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A study of tableting materials and tablets with the combination of microcrystalline celulose and mannitol for orally disintegrating tablets.
Novotná, Andrea ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Andrea Novotná Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of tableting materials and tablets with the combination of microcrystalline cellulose and mannitol for orally disintegrating tablets This thesis compares co-processed dry binder Avicel® HFE-102 containing 90 % microcrystalline cellulose and 10 % mannitol with a physical mixture of related dry binders, microcrystalline cellulose (Avicel® PH-102) and mannitol (Pearlitol® 100SD) in the ratio of 9:1. Flow properties, compressibility, lubricant sensitivity, tensile strength and disintegration time of tablets are evaluated. Compressibility is evaluated by means of the energy profile of compression process, and lubricant sensitivity by means of the lubricant sensitivity ratio. The results are also compared with the microcrystalline cellulose for direct compression Avicel® PH-102 alone. The flow properties of the co-processed dry binder Avicel® HFE-102 alone and the physical mixture were comparable. Avicel® HFE-102 showed higher values of the energy of plastic deformation, tensile strength of tablets, and a markedly lower lubricant sensitivity than the physical mixture of dry binders. Tablets with the...
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A study of the coprocessed dry binder with mannitol, lactose, dextrose and crospovidone for orally disintegrating tablets.
Bímová, Daniela ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Daniela Bímová Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of the coprocessed dry binder with mannitol, lactose, dextrose and crospovidone for orally disintegrating tablets. This work evaluates and compares directly compressible tableting materials and tablets with Disintequik® ODT, which is used for the production of orodispersible tablets. The effect of three lubricants in two concentrations (0.5 and 1 %) on the properties of tableting materials and tablets is evaluated. Tested lubricants are magnesium stearate, calcium stearate and sodium stearyl fumarate. The tested parameters are flow properties, further compressibility, ejection force, tensile strength and disintegration time of tablets in the dependence on compression force. The compressibility is evaluated by the energy profile of the compression process. The lubricants improved the flowability of Disintequik® ODT and the best values were in the case of calcium stearate. The total energy of the compression increased with the compression force and the highest values were seen in the tableting materials with magnesium stearate. The values of plasticity decreased with the compression force. The ejection...
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The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets.
Rumlerová, Lenka ; Ondrejček, Pavel (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Department of Pharmaceutical Technology Consultant: PharmDr. Pavel Ondrejček, Ph.D Student: Lenka Rumlerová Title of Thesis: The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets. This thesis deals with influence of rice extract, as a new kind of glidant on compressibility of microcrystalline celulose as a model filler. Furthermore it evaluates the impact of rice extract on tablet properties. Effects of rice extract were compared with two standard glidants - magnesium stearate and colloidal silicon dioxide. As first the influence of diferent glidants concetrations on flow properties of mixtures were assesed. Tablets were compresed using three different compression forces. A force- displacement record was used to evaluate the compressibility of microcrystalline cellulose and its mixtures with glidants. Subsequently, the properties of tablets were evaluated. The radial strenght, abrasion, and tablet disintegration time were measured. The results revealed that the rice extract has the least effect on mixtures flow poperties. However, all mixtures showed a statistically significant improvement in flowability. When using a 1 % rice extract, the flow properties of the...
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