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Microfibers based on polyhydroxybutyrate for medical applications
 Gregušková, Zuzana ; Obruča, Stanislav (oponent) ; Přikryl, Radek (vedoucí práce)
Master’s thesis targets microfibers based on biopolymer poly(3-hydroxybutyrate) and their use in medical applications. The theoretical part deals with a study of the microfibers creation process using the technology of centrifugal spinning, its kinetics and factors influencing the creation and properties of prepared microfibres. Subsequently, the theoretical part orientates on a short overview of biopolymers used in the technology, characterization of material poly(3-hydroxybutyrate). It also presents a proposal of a potential target application of the microfibres. The experimental part concentrates on microfibers preparation from the mentioned poly(3-hydroxybutyrate). Several parameters leading to better spinnability of the material are tracked and optimized. The practical part is extended by modifying the polymer solution by adding other biopolymers and plasticizers and producing microfibres from the polymer mixture thus treated. Attention is also paid to the optimization of process parameters. Moreover, the prepared microfibres are analyzed and characterized by several methods and compared to develop a suitable alternative to currently used substrates for cell growth in 3D.
Úplný záznam
Microfibers based on polyhydroxybutyrate for medical applications
 Gregušková, Zuzana ; Obruča, Stanislav (oponent) ; Přikryl, Radek (vedoucí práce)
Master’s thesis targets microfibers based on biopolymer poly(3-hydroxybutyrate) and their use in medical applications. The theoretical part deals with a study of the microfibers creation process using the technology of centrifugal spinning, its kinetics and factors influencing the creation and properties of prepared microfibres. Subsequently, the theoretical part orientates on a short overview of biopolymers used in the technology, characterization of material poly(3-hydroxybutyrate). It also presents a proposal of a potential target application of the microfibres. The experimental part concentrates on microfibers preparation from the mentioned poly(3-hydroxybutyrate). Several parameters leading to better spinnability of the material are tracked and optimized. The practical part is extended by modifying the polymer solution by adding other biopolymers and plasticizers and producing microfibres from the polymer mixture thus treated. Attention is also paid to the optimization of process parameters. Moreover, the prepared microfibres are analyzed and characterized by several methods and compared to develop a suitable alternative to currently used substrates for cell growth in 3D.
Úplný záznam

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