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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Evaluation of strategies for humanization of the entire porcine HTT locus
 Vochozková, Petra ; Klymiuk, N. ; Wolf, E. ; Ellederová, Zdeňka ; Motlík, Jan
Because fully suitable large animal models are still lacking for Huntington´s disease, we would like to generate a new minipig model which will have an entirely humanized HTT locus. Given the large size of the HTT gene (approx. 160 kb) we will test two different approaches to humanize the porcine HTT locus in porcine kidney cells (PKCs).
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Marcus Aurelius and The Meditations
 Wolf, Edita ; Thein, Karel (advisor) ; Mikeš, Vladimír (referee)
The classification of the Meditations of Marcus Aurelius as a spiritual exercise by Pierre Hadot has been widely accepted and exerts a strong influence on any interpretation of the text. However, such genre categorization is by itself an interpretative choice excluding other possible readings. The present thesis offers a new reading of the Meditations based on Gilles Deleuze's interpretation of stoicism and on his philosophy of event. This reading avoids any genre classification and focuses instead on the text itself by analyzing the changes of linguistic person. The Deleuzian interpretation of linguistic person and his concept of event allow for explanation of this particular feature of the Meditations and thus for addressing the problem of person and individual in stoic philosophy. Furthermore, the Deleuzian framework makes it possible to explore significant, but up to now marginalized themes recurring in the text that are directly linked to the problem of individuation - non-tragic theatre and death.
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1 Wolf, Edita
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