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Contribution to optimization of parameters of speciation analysis of As based on selective hydride generation in direct transfer mode and detection by atomic absorption spectrometry
Vyvadilová, Tereza ; Dědina, Jiří (advisor) ; Korunová, Vlasta (referee)
The presented thesis deals with optimization of parameters speciation analysis based on a selective hydride generation in a direct transfer mode of hydrides and on-line atomization in an atomic absorption spectrometer. In the first part of the thesis processes during generation were investigated. Important indicator of a reactions taking place in a generator is volume of hydrogen (created by decomposition of NaBH4) which is subsequently introduced to the atomizer. In this part of the thesis a new approach to determine a flow rate of hydrogen delivered to the atomizator was developed. An influence of relevant paremeters of the atomizers and atomic absorption spectrometers on basic analytical characteristics of arsenic determination based on hydride generation was performed in the second part. Three atomic absorption spectrometers were used and three sources of radiation were compared. The most important analytic characteristic was the limit of detection which is influenced by standard deviation of measurement values of blank samples and by sensitivity. The best values of the limit of detection were achieved with electrodeless discharge lamps. Key words: hydride generation, arsenic, speciation analysis, atomic absorption spectrometry
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Importance of particular regions of CNS in the development of opioid addiction
Vyvadilová, Tereza ; Hejnová, Lucie (advisor) ; Roubalová, Lenka (referee)
Opiods are used as the most powerful painkillers in the medicine. The mechanism of their effect is determined by binding to the opioids receptors located in the central nervous system and peripheral nervous system. The opioids have high potential to develop addiction. Significance of psychical addiction belongs to losing control above using and compulsive desire to obtain drug of abuse to achieve certain psychical state. The somatic part is increase tolerance demonstrating need of dose increasing to achieve required effect. This thesis summarizes knowledge about particular regions of the central nervous system which participate on developing of addiction as ventral tegmental area, nucleus accumbens, locus coeruleus, ventral pallidum and amygdala. It seems that main role in developing of addiction acts the mesolimbic reward system which relates with increased release of dopamine resulting in stimulation of the brain reward system.
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Contribution to optimization of parameters of speciation analysis of As based on selective hydride generation in direct transfer mode and detection by atomic absorption spectrometry
Vyvadilová, Tereza ; Dědina, Jiří (advisor) ; Korunová, Vlasta (referee)
The presented thesis deals with optimization of parameters speciation analysis based on a selective hydride generation in a direct transfer mode of hydrides and on-line atomization in an atomic absorption spectrometer. In the first part of the thesis processes during generation were investigated. Important indicator of a reactions taking place in a generator is volume of hydrogen (created by decomposition of NaBH4) which is subsequently introduced to the atomizer. In this part of the thesis a new approach to determine a flow rate of hydrogen delivered to the atomizator was developed. An influence of relevant paremeters of the atomizers and atomic absorption spectrometers on basic analytical characteristics of arsenic determination based on hydride generation was performed in the second part. Three atomic absorption spectrometers were used and three sources of radiation were compared. The most important analytic characteristic was the limit of detection which is influenced by standard deviation of measurement values of blank samples and by sensitivity. The best values of the limit of detection were achieved with electrodeless discharge lamps. Key words: hydride generation, arsenic, speciation analysis, atomic absorption spectrometry
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Importance of particular regions of CNS in the development of opioid addiction
Vyvadilová, Tereza ; Hejnová, Lucie (advisor) ; Roubalová, Lenka (referee)
Opiods are used as the most powerful painkillers in the medicine. The mechanism of their effect is determined by binding to the opioids receptors located in the central nervous system and peripheral nervous system. The opioids have high potential to develop addiction. Significance of psychical addiction belongs to losing control above using and compulsive desire to obtain drug of abuse to achieve certain psychical state. The somatic part is increase tolerance demonstrating need of dose increasing to achieve required effect. This thesis summarizes knowledge about particular regions of the central nervous system which participate on developing of addiction as ventral tegmental area, nucleus accumbens, locus coeruleus, ventral pallidum and amygdala. It seems that main role in developing of addiction acts the mesolimbic reward system which relates with increased release of dopamine resulting in stimulation of the brain reward system.
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