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A study of micronized poloxamers as lubricants in direct compression of tablets.
Vyhlídalová, Barbora ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
The study evaluates the micronized poloxamers Lμtrol® micro 127 (poloxamer 407) and Lμtrol® micro 68 (poloxamer 188) as lubricants in combination with the dry binders microcrystalline celulose and spray-dried lactose. Magnesium stearate was employed as the comparative lubricant. The parameters under study included energy for fiction, plasticity, ejection force, and tensile strength of tablets. The factors of influence were the concentration of lubricants, compression force, and mixing parameters. The lubricating effect of micronized poloxamers was smaller than that of magnesium stearate. Higher concentrations of poloxamers decreased the tensile strength of tablets from microcrystalline cellulose. Parameters of mixing of dry binders with poloxamers influenced the tested parameters of compression more than those with magnesium stearate, in particular in the case of spray-dried lactose. In microcrystalline cellulose, they influenced more the tensile strength of tablets.
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The study of directly compressible tableting materials with agglomerated α - lactose monohydrate and lubricants
Vyhlídalová, Barbora ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical Technology Candidate Mgr. Barbora Vyhlídalová Consultant PharmDr. Jitka Mužíková, Ph.D. Title of the Thesis The study of directly compressible tableting materials with agglomerated α - lactose monohydrate and lubricants This work deals with the study of tabletting materials, which contain agglomerated α- lactose monohydrate (Tablettosa® 80) and four types of lubricants at concentration of 1%. The used lubricants were magnesium stearate, calcium stearate, sodium-stearyl-fumarate and glyceryl behenate. Flow properties of the mixtures, energy profile of the compression process, ejection force, tensile strength and disintegration time of tablets were evaluated. The compression parameters and the properties of tablets were evaluated depending on the compressiion force. The flow properties were most improved by magnesium stearate. Glyceryl behenate didn't affect them. Total energy of the compression process increased with increasing compression force. The mixture with calcium stearate had the lowest value of total energy and the mixture with sodium-stearyl-fumarate had the highest value. Plasticity decreased with increasing compression force. Values of the ejection force showed that glyceryl behenate can't be used at...
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The study of directly compressible tableting materials with agglomerated α - lactose monohydrate and lubricants
Vyhlídalová, Barbora ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical Technology Candidate Mgr. Barbora Vyhlídalová Consultant PharmDr. Jitka Mužíková, Ph.D. Title of the Thesis The study of directly compressible tableting materials with agglomerated α - lactose monohydrate and lubricants This work deals with the study of tabletting materials, which contain agglomerated α- lactose monohydrate (Tablettosa® 80) and four types of lubricants at concentration of 1%. The used lubricants were magnesium stearate, calcium stearate, sodium-stearyl-fumarate and glyceryl behenate. Flow properties of the mixtures, energy profile of the compression process, ejection force, tensile strength and disintegration time of tablets were evaluated. The compression parameters and the properties of tablets were evaluated depending on the compressiion force. The flow properties were most improved by magnesium stearate. Glyceryl behenate didn't affect them. Total energy of the compression process increased with increasing compression force. The mixture with calcium stearate had the lowest value of total energy and the mixture with sodium-stearyl-fumarate had the highest value. Plasticity decreased with increasing compression force. Values of the ejection force showed that glyceryl behenate can't be used at...
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A study of micronized poloxamers as lubricants in direct compression of tablets.
Vyhlídalová, Barbora ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
The study evaluates the micronized poloxamers Lμtrol® micro 127 (poloxamer 407) and Lμtrol® micro 68 (poloxamer 188) as lubricants in combination with the dry binders microcrystalline celulose and spray-dried lactose. Magnesium stearate was employed as the comparative lubricant. The parameters under study included energy for fiction, plasticity, ejection force, and tensile strength of tablets. The factors of influence were the concentration of lubricants, compression force, and mixing parameters. The lubricating effect of micronized poloxamers was smaller than that of magnesium stearate. Higher concentrations of poloxamers decreased the tensile strength of tablets from microcrystalline cellulose. Parameters of mixing of dry binders with poloxamers influenced the tested parameters of compression more than those with magnesium stearate, in particular in the case of spray-dried lactose. In microcrystalline cellulose, they influenced more the tensile strength of tablets.
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