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Phototherapy in dermatovenereology - methods and mechanisms
Benáková, Nina ; Cetkovská, Petra (advisor) ; Ditrichová, Dagmar (referee) ; Pavel, Stanislav (referee) ; Vašků, Vladimír (referee)
I choose the topic of phototherapy because of my longlasting interest in this field. Phototherapy is defined as the therapeutic use of light, primarily ultraviolet light. The mode of action on the skin is described as photobiological one and it has been continuously investigated. At its most basic level phototherapy represents the application of energy to skin, which means the delivery of photons to chromophores, the absorbtion of photons in chromophores and the biologic reaction of photon's absorbed energy. This causes the formation of heat and various biochemical effects in the skin. Previously the main role of UV light in phototherapy was thought to be the antimitotic and antiproliferative. Nowadays it is clear that beside them the mode of action is rather immunomodulatory and immunosuppressive. Further possible mechanism of the UV light are detected with increasing investigation of the immune system of skin. The rules and usages of phototherapy in practice at individual dermatological departments and offices differ and there is a need to improve and/or coordinate the protocols in order to reach the optimal risk/benfit ratio. That was one of the reasons for conducting the epidemiological study Phototherapy in Czech Republic. The results shows phototherapy to be an available and relative...
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New Diagnostic Methods in Dermatology: Non-invasive Diagnosis of Non-melanoma Skin Cancer
Kříž, Martin ; Arenberger, Petr (advisor) ; Pavel, Stanislav (referee) ; Vašků, Vladimír (referee)
Non-melanoma skin cancer (NMSC) is the most prevalent cancer in the light-skinned population. New less- or non-invasive treatments are increasingly used for NMSC patients, making the development of non-invasive diagnostic technologies highly relevant. The scope of this work is to present data on the current state-of-art in diagnostic methods for NMSC and actinic keratosis. Different key words were searched through scientific search-engines. Results of the two of our studies are presented. Encouraging results from the reviewed diagnostic trials have suggested a high diagnostic accuracy for many of the new technologies. New imaging technologies have the capability of providing new or additional data or enough information in vivo to understand of NMSC development and to help the clinical diagnostics. Some of the new technologies, especially the high frequency ultrasonography described in the paper have the potential to be used in the daily praxis of NMSC diagnostic. The fluorescence diagnostic brings in our point of view a great merit in second line diagnostics of advanced and not clear cases.
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New Diagnostic Methods in Dermatology: Non-invasive Diagnosis of Non-melanoma Skin Cancer
Kříž, Martin ; Arenberger, Petr (advisor) ; Pavel, Stanislav (referee) ; Vašků, Vladimír (referee)
Non-melanoma skin cancer (NMSC) is the most prevalent cancer in the light-skinned population. New less- or non-invasive treatments are increasingly used for NMSC patients, making the development of non-invasive diagnostic technologies highly relevant. The scope of this work is to present data on the current state-of-art in diagnostic methods for NMSC and actinic keratosis. Different key words were searched through scientific search-engines. Results of the two of our studies are presented. Encouraging results from the reviewed diagnostic trials have suggested a high diagnostic accuracy for many of the new technologies. New imaging technologies have the capability of providing new or additional data or enough information in vivo to understand of NMSC development and to help the clinical diagnostics. Some of the new technologies, especially the high frequency ultrasonography described in the paper have the potential to be used in the daily praxis of NMSC diagnostic. The fluorescence diagnostic brings in our point of view a great merit in second line diagnostics of advanced and not clear cases.
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Phototherapy in dermatovenereology - methods and mechanisms
Benáková, Nina ; Cetkovská, Petra (advisor) ; Ditrichová, Dagmar (referee) ; Pavel, Stanislav (referee) ; Vašků, Vladimír (referee)
I choose the topic of phototherapy because of my longlasting interest in this field. Phototherapy is defined as the therapeutic use of light, primarily ultraviolet light. The mode of action on the skin is described as photobiological one and it has been continuously investigated. At its most basic level phototherapy represents the application of energy to skin, which means the delivery of photons to chromophores, the absorbtion of photons in chromophores and the biologic reaction of photon's absorbed energy. This causes the formation of heat and various biochemical effects in the skin. Previously the main role of UV light in phototherapy was thought to be the antimitotic and antiproliferative. Nowadays it is clear that beside them the mode of action is rather immunomodulatory and immunosuppressive. Further possible mechanism of the UV light are detected with increasing investigation of the immune system of skin. The rules and usages of phototherapy in practice at individual dermatological departments and offices differ and there is a need to improve and/or coordinate the protocols in order to reach the optimal risk/benfit ratio. That was one of the reasons for conducting the epidemiological study Phototherapy in Czech Republic. The results shows phototherapy to be an available and relative...
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