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Synthesis of Steroid Derivatives for In Vitro Diagnostics.
Kos, Martin ; Váňa, Lubomír ; Žádný, Jaroslav ; Storch, Jan
This work is focused on the synthesis of novel steroidal androgen derivatives consisting of a steroidal skeleton, a spacer and imidazole ring or a primary amine functional group. The starting material for the synthesis is represented by commercial available hydroxy-androgens, which are further modified. First, the hydroxyl group is attached to the spacer and then connected to the desired imidazole or the protected primary amine. The above described derivatives will be utilized for development of analytical kits for a determination of the free steroid hormone.
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Transition Metals Complexes with Helical 2,2´-Bipyridine Ligands.
Kos, Martin
Herein we report synthesis of series of novel chiral complexes of various metals (Cu, Re, etc.) with helical ligands containing bipyridine moiety (Fig. 1). Photochemical and photophysical properties of prepared complexes will be studied in both racemic and optical pure form.
Fulltext: content.csg - PDF
Plný tet: SKMBT_C22018060408150 - PDF
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Photochemical Synthesis of Aza-aromatic Compounds.
Kos, Martin ; Žádný, Jaroslav ; Storch, Jan ; Sýkora, Jan ; Církva, Vladimír
Herein we report synthesis of series of novel both aza- and diaza-helicenes, and phenacenes, which were prepared mainly by photocyclization of corresponding imine precursors. Reaction conditions of photocyclization (i.e. solvent, photocatalyst, type of irradiation, use of water scavenger) were optimized and enhanced. Usage of TEMPO as oxidizing agent leads to improvement of yields up to 72 %. Prepared 2-pyridyl substituted azaphenacenes will be utilized for preparation of potential semiconductive layers in cooperation with IMC of the CAS.
Fulltext: content.csg - PDF
Plný tet: SKMBT_C22017111612580 - PDF
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Vliv délky světelného dne na příjem krmiva a růst síha peledě (Coregonus peled) v intenzivním chovu
KOS, Martin
The effect of the length of the daylight on growth of in peled (Coregonus peled) juveniles was tested in the intensive culture. Fish of mean body weight 1.82 +- 0.48 g and total length of 65 +- 7 mm were divided into four groups (the ratio of light and darkness 12k12, 16k8, 20k4, 24k0). The experiment lasted for sixty-three days. Every twenty-one days fishes were sampled for biometric measurements. Fish reached mean body weight of 15 +- 4.9 g (12k12); 15.6 +- 4.5 g (16k8); 16.7 +- 4.5 g (20k4); 16.8 +- 5 g (24k0) in experimental groups. The longest total body length was detected in both 20k4 and 24k0 groups (127 +- 11 mm). The lowest one was registered in the 16k8 (114 +- 11 mm). The highest condition coefficient had group 16k8 and lowest was found out in group 20k4. Specific growth rate during the course of the experiment was 3.33 %xday -1 (12k12); 3.28 %xday -1 (16k8); 3.49 %xday -1 (20k4) and 3.43 % xday -1 (24k0). The highest final survival (95.8 +- 1.4 %) was achieved in group 12k12. On the contrary, group 16k8 showed lowest survival of 90.0 +- 4.6 %. There were no significant differences in final survival rate.
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