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Neuropsychiatric and cognitive aspects of early stages of Alzheimer's disease and other neurodegenerative disorders in late-life
Matušková, Veronika ; Vyhnálek, Martin (advisor) ; Kopeček, Miloslav (referee) ; Mitterová, Kristína (referee)
Neuropsychiatric and cognitive aspects of early stages of Alzheimer's disease and other neurodegenerative disorders in late-life Abstract The early diagnosis of Alzheimer's disease (AD) is currently focused on the stages preceding the dementia syndrome, i.e. the preclinical stage and the mild cognitive impairment (MCI) stage. However, the detection of AD using specific biomarkers of beta amyloid and tau protein is limited in clinical practice and often costly or invasive. Therefore, the detection of early clinical signs of AD continues to be invaluable. The aim of this dissertation is to contribute to the early diagnosis of AD by examining specific cognitive markers as well as neuropsychiatric symptoms (NPS), which have so far received little research and clinical attention. The first study introduces criteria for what is termed mild behavioral impairment (MBI), a syndrome analogous to mild cognitive impairment (MCI) describing new-onset and persistent NPS in older adults, and maps MBI symptoms across the cognitive spectrum with the Mild Behavioral Impairment Checklist (MBI-C), translated and adapted in this study. The second study shows that the severity of MBI-C symptoms, particularly impulse dyscontrol and decreased motivation in non-demented older adults, is associated with lower volume or thickness of...
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Evaluation of psychomotor speed in patients with depressive disorder
Kostúrová, Rút ; Kopeček, Miloslav (advisor)
Depression is závažným health problem that is manifested in increasing quantity of people at different ages. It hasconsequences for both medical (sebevraždy, abuse alcohol and drugs, the complications of otherdiseases such as as cardiovascular disease, various endocrine diseases, dementia, oncological diseases, etc.) and socioeconomic (sick leave people of working age, greater consumption of medical care,manželství decays, impaired child care, etc.), WHO estimates that by 2020 depressionwill become second leading cause of disability, morbidity and mortality in the world immediately after coronary heart disease. (Grammenos, 2005) is therefore general trend to move diagnosis and treatment of depressivedisorders at the level primary care physicians to first contact
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The Utility of Spatial Navigation and Metabolic Biomarkers in Early and Differential Diagnosis of Neurodegenerative Diseases
Cerman, Jiří ; Laczó, Jan (advisor) ; Roth, Jan (referee) ; Kopeček, Miloslav (referee)
Alzheimer's disease (AD) is the most common neurodegenerative disease leading to dementia and represents a significant socio-economic problem. Currently, only symptomatic treatment of AD is possible and the development of new causal therapy faces a number of difficulties, which are inter alia related to identifying early stages and the possibilities of differential diagnosis of specific neurodegenerative diseases. Therefore, in recent years, methods that are easily available and able to reliably identify individuals at risk of developing AD already at preclinical and prodromal stages are of particular interest. The work presents a basic overview of the current knowledge about neurodegenerative diseases and especially AD and extends the knowledge in this area. The main goals of the thesis are to map out the potential contribution of spatial navigation testing as a new experimental method, which is suitable for early diagnosis and differential diagnosis of advanced stages of neurodegenerative diseases, and to evaluate the benefits of metabolic biomarker testing in clinical practice. In the early stages of neurodegenerative diseases, the work focuses primarily on the evaluation of impairment of a specific type of spatial navigation - path integration in patients with AD and also on subjective spatial...
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The Utility of Spatial Navigation and Metabolic Biomarkers in Early and Differential Diagnosis of Neurodegenerative Diseases
Cerman, Jiří ; Laczó, Jan (advisor) ; Roth, Jan (referee) ; Kopeček, Miloslav (referee)
Alzheimer's disease (AD) is the most common neurodegenerative disease leading to dementia and represents a significant socio-economic problem. Currently, only symptomatic treatment of AD is possible and the development of new causal therapy faces a number of difficulties, which are inter alia related to identifying early stages and the possibilities of differential diagnosis of specific neurodegenerative diseases. Therefore, in recent years, methods that are easily available and able to reliably identify individuals at risk of developing AD already at preclinical and prodromal stages are of particular interest. The work presents a basic overview of the current knowledge about neurodegenerative diseases and especially AD and extends the knowledge in this area. The main goals of the thesis are to map out the potential contribution of spatial navigation testing as a new experimental method, which is suitable for early diagnosis and differential diagnosis of advanced stages of neurodegenerative diseases, and to evaluate the benefits of metabolic biomarker testing in clinical practice. In the early stages of neurodegenerative diseases, the work focuses primarily on the evaluation of impairment of a specific type of spatial navigation - path integration in patients with AD and also on subjective spatial...
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Evaluation of psychomotor speed in patients with depressive disorder
Kostúrová, Rút ; Kopeček, Miloslav (advisor)
Depression is závažným health problem that is manifested in increasing quantity of people at different ages. It hasconsequences for both medical (sebevraždy, abuse alcohol and drugs, the complications of otherdiseases such as as cardiovascular disease, various endocrine diseases, dementia, oncological diseases, etc.) and socioeconomic (sick leave people of working age, greater consumption of medical care,manželství decays, impaired child care, etc.), WHO estimates that by 2020 depressionwill become second leading cause of disability, morbidity and mortality in the world immediately after coronary heart disease. (Grammenos, 2005) is therefore general trend to move diagnosis and treatment of depressivedisorders at the level primary care physicians to first contact
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