National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
název v anglickém jazyce není uveden
Křemen, Jaromír ; Haluzík, Martin (advisor) ; Stárka, Luboslav (referee) ; Zadák, Zdeněk (referee)
Insulin resistance is one of hot topics of present medicine not only in its braches focused on civilization diseases such as diabetology or obesitology but also in other fields, namely in intensive care medicine. Hyperglycemia caused by accelerated insulin resistance is observed in critically ill patients very often. It has many undesirable effects and potential complications. This phenomenon is caused by a network of different mechanisms, especially by systemic inflammatory response and subsequent burst of stress hormones and proinflammatory cytokines which directly participate in the ethiopatogenesis of insulin resistance. Recent investigations documented that many of proinflammatory cytokines are directly produced by adipose tissue. Although basic mechanisms of insulin resistance and type 2 type diabetes mellitus in obese subjects are somewhat different in both pathologie overproduction of some proinflammatory cytokines by adipose tissue may play a role. It has been demonstrated that correction of hyperglycemia in criticially ill patient by intensive insulin therapy leads to reduction of thein morbidity and mortality. Tight glycemic control requires a frequent blood glukose measueremnts increasing the workload of ICU personnel Therefore, the development of systems for continuous measuring of glycemia and...

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8 Křemen, Jan
3 Křemen, Jaroslav
2 Křemen, Josef
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