|
|
Transport properties of hyaluronan-based hydrogel systems
Káčeríková, Martina ; Smilek, Jiří (referee) ; Klučáková, Martina (advisor)
This bachelor thesis deals with the study of trasport properties of hydrogels, that were prepared by interaction of hyaluronan with karbethopendecinium bromide (Septonex), as a surfactant. Nile red is a fluorescent probe to determine the ability of the system to absorb or to release the substance. All the hydrogels were prepared by the „wet“ way, where the solutions of hyaluronan and surfactant were prepared first. Nile red was prepared in the solution of tenzide, which after the mixing with hyaluronan produced colorful gels. By the spectrophotometric measurement, the absorbance of supernatants were observed. The absorbance was measured in original but also in changed supernatatns after 24, 72 and 168 hours.
|
|
|
Development of organic UV filtres based on natural extracts
Káčeríková, Martina ; Kovalčík, Adriána (referee) ; Márová, Ivana (advisor)
This diploma thesis is focused on the development of organic UV filters. Organic UV filters were extracted from natural resources and encapsulated into nanomaterial-like delivery systems such as liposomes and nanofibres. SPF of particular extracts and carriers with encapsulated extracts were measured. All of the prepared extracts as well as carriers were characterised for their content of natural substances like phenolic compounds and their antioxidant acitvity, stability, cytotoxicity, micriobial acitivity and their safety were studied too. All of the prepared materials were evaluated as suitable for use in comestic industry. However, in a future, it would be appropriate to add to the study other experimental methods to increase the active substances and at the same time increase the SPF protection factor.
|
|
|
Development of organic UV filtres based on natural extracts
Káčeríková, Martina ; Kovalčík, Adriána (referee) ; Márová, Ivana (advisor)
This diploma thesis is focused on the development of organic UV filters. Organic UV filters were extracted from natural resources and encapsulated into nanomaterial-like delivery systems such as liposomes and nanofibres. SPF of particular extracts and carriers with encapsulated extracts were measured. All of the prepared extracts as well as carriers were characterised for their content of natural substances like phenolic compounds and their antioxidant acitvity, stability, cytotoxicity, micriobial acitivity and their safety were studied too. All of the prepared materials were evaluated as suitable for use in comestic industry. However, in a future, it would be appropriate to add to the study other experimental methods to increase the active substances and at the same time increase the SPF protection factor.
|
|
|
Transport properties of hyaluronan-based hydrogel systems
Káčeríková, Martina ; Smilek, Jiří (referee) ; Klučáková, Martina (advisor)
This bachelor thesis deals with the study of trasport properties of hydrogels, that were prepared by interaction of hyaluronan with karbethopendecinium bromide (Septonex), as a surfactant. Nile red is a fluorescent probe to determine the ability of the system to absorb or to release the substance. All the hydrogels were prepared by the „wet“ way, where the solutions of hyaluronan and surfactant were prepared first. Nile red was prepared in the solution of tenzide, which after the mixing with hyaluronan produced colorful gels. By the spectrophotometric measurement, the absorbance of supernatants were observed. The absorbance was measured in original but also in changed supernatatns after 24, 72 and 168 hours.
|
guest ::
