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The role of WT1 gene and other molecular biological abnormalities in testicular germ cell tumors
Bakardjieva - Mihaylova, Violeta ; Boublíková, Ludmila (advisor) ; Chovanec, Michal (referee) ; Kiss, Igor (referee)
Testicular germinal tumors (TGCT) are relatively rare solid tumors in adults. Even so, they affect more than 700 men a year in the Czech Republic, mostly young patients aged 18- 45 years. A large number of patients are curable by a combination of surgery and chemotherapy, yet about 50 men a year in the Czech Republic succumb to this tumor, in the vast majority of cases due to the development of resistance to chemotherapy containing cisplatin. The rare occurrence and high curability are probably the cause of infrequent molecular and clinical studies carried out in these tumors, and our understanding of the biological processes leading to primary tumor development and the development of cisplatin resistance (CDDP) is still limited. At present, no specific molecular markers that could be used as prognostic or predictive factors and improve patient stratification or treatment tailoring are available in TGCT management. In this work, we studied the molecular-genetic background of TGCT development and CDDP resistance at several levels. To comprehensively study the development of cisplatin resistance, we prepared and analyzed CDDP-exposed TGCT cell lines. Long-term exposure to CDDP increased resistance 10-fold in the NCCIT cell line, while no significant resistance was achieved with Tera-2. The...
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Women and pornography
Chovanec, Michal ; Weiss, Petr (advisor) ; Chochola, Martin (referee) ; Uzel, Radim (referee)
Aims: to explore if the consumption of pornography have influence on a relationship, if the consumption of pornography have a negative impact on a first intercourse and on a initial masturbation behavior, to find out if it is a difference between younger and older women in the frequency of pornography consumption, explore if religiosity have some impact on frequency of pornography consumption and one of the aims is to disrupt the myth about primary pornography consumption by men. Method: the representative data vere collected from 413 Slovak women, the data were based on a quota sampling by agency 2muse according to three categories (age, education and address), the sample age was from 18 to 77 years old and average age was 40 years old (SD±14,62). Results: average age of first pornography consumption is 20,01 years old (SD±7,56), the most interesting age of pornography consumption is 23,44 (SD±9,12). The frequency of pornography consummation is couple of times per year for 107 (25,9%) respondents and most often is watching less than 5 minutes per day. Religiosity has a protective factor of frequency of pornography consumption depending of strengths of religious beliefs and the frequency of implementation of religious requirements. Pornography is not an accelerating factor an initial masturbating...
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Porovnání organických antikorozních nátěrových systémů
Chovanec, Michal
The bachelor thesis is aimed on anti-corrosion organic paint coats. In the thesis is described general comparison of synthetic and water-dilutable paint coats on the pretreated metal surface (used in mechanical engineering). In the beginning, there is definition of corrosion and it´s basic division to uniform and non-uniform corrosion. In the second part of the thesis is described pre-treatment of material before the application of the mechanical, chemical or electrochemical anti-corrosion protection. Each step of the pre-treatment is divided by the individual method. The next section includes characteristics of the synthetic and water-dilutable paint coats and different types of their usage. The final chapter is aimed on suitability of the specific paint coat, based on technical specification of coating, to the different environment.
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The role of WT1 gene and other molecular biological abnormalities in testicular germ cell tumors
Bakardjieva - Mihaylova, Violeta ; Boublíková, Ludmila (advisor) ; Chovanec, Michal (referee) ; Kiss, Igor (referee)
Testicular germinal tumors (TGCT) are relatively rare solid tumors in adults. Even so, they affect more than 700 men a year in the Czech Republic, mostly young patients aged 18- 45 years. A large number of patients are curable by a combination of surgery and chemotherapy, yet about 50 men a year in the Czech Republic succumb to this tumor, in the vast majority of cases due to the development of resistance to chemotherapy containing cisplatin. The rare occurrence and high curability are probably the cause of infrequent molecular and clinical studies carried out in these tumors, and our understanding of the biological processes leading to primary tumor development and the development of cisplatin resistance (CDDP) is still limited. At present, no specific molecular markers that could be used as prognostic or predictive factors and improve patient stratification or treatment tailoring are available in TGCT management. In this work, we studied the molecular-genetic background of TGCT development and CDDP resistance at several levels. To comprehensively study the development of cisplatin resistance, we prepared and analyzed CDDP-exposed TGCT cell lines. Long-term exposure to CDDP increased resistance 10-fold in the NCCIT cell line, while no significant resistance was achieved with Tera-2. The...
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Women and pornography
Chovanec, Michal ; Weiss, Petr (advisor) ; Chochola, Martin (referee) ; Uzel, Radim (referee)
Aims: to explore if the consumption of pornography have influence on a relationship, if the consumption of pornography have a negative impact on a first intercourse and on a initial masturbation behavior, to find out if it is a difference between younger and older women in the frequency of pornography consumption, explore if religiosity have some impact on frequency of pornography consumption and one of the aims is to disrupt the myth about primary pornography consumption by men. Method: the representative data vere collected from 413 Slovak women, the data were based on a quota sampling by agency 2muse according to three categories (age, education and address), the sample age was from 18 to 77 years old and average age was 40 years old (SD±14,62). Results: average age of first pornography consumption is 20,01 years old (SD±7,56), the most interesting age of pornography consumption is 23,44 (SD±9,12). The frequency of pornography consummation is couple of times per year for 107 (25,9%) respondents and most often is watching less than 5 minutes per day. Religiosity has a protective factor of frequency of pornography consumption depending of strengths of religious beliefs and the frequency of implementation of religious requirements. Pornography is not an accelerating factor an initial masturbating...
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