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Monitoring of Pleural Effusion Parameters During the Treatment of Chest Empyema
Matuchová, Inka ; Krejsek, Jan (advisor) ; Bobek, Vladimír (referee) ; Vodička, Josef (referee)
Monitoring of pleural effusion parameters during the treatment of chest empyema Chest empyema is a severe complication with collection of pus in the pleural cavity. The mortality rate of chest empyema is up to 40 %. Generally, treatment involves a drain insertion into the inflammatory focus and pleural space irrigation with local application of medication. These processes are usually lengthy with high risk of relapse. Our aim is to shorten the period of treatment using cytological-energy analysis of pleural effusions. This approach is based on simultaneous cytological and metabolic investigation of the pleural effusions. Results allow us to determine the type and intensity of local immune response in the pleural cavity. Repetitive investigations of pleural effusions in time give us information aiming the development of local immunity response in the pleural cavity and can follow the effect of therapy. Our goal is to define the theoretical framework for application of cytological-energy analysis of pleural effusions in patients with chest empyemas. The determination of the catalytic activities of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) in pleural effusions as parameters of tissue damage is introduced by us. We established that cytological-energy analysis of pleural effusion...
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Rare cells in diagnostics and monitoring of gynecological diseases
Kiss, Imrich ; Bobek, Vladimír (advisor) ; Špaček, Jiří (referee) ; Klézl, Petr (referee)
In the last two decades there is an enormous effort to discover a non-invasive marker to diagnose, predict and monitor therapy effect of malignant diseases. Circulating tumor cells (CTC) have the ability to fulfil all these criteria. The introduction of the monothematic thesis deals with the problematics of CTC in general and its application in clinical medicine. It is followed by the author's first publication, which reviews the current status of CTC in gynecological malignancies. The next publication is an original article about CTC in patients with endometrial carcinoma. It reports a successful isolation of vital CTC in 75% of tested patients and identifies CTC as an individual marker of the disease without correlation to the stage, grade or lymph nodes involvement. The second part of this thesis deals with endometriosis, a benign but often recurrent disease worsening the life quality of women in reproductive age. The multicentre study presents a successful isolation of circulating endometrial cells (CEC) in patients with histologically proven endometriosis with various stages and symptoms. From the total of 423 samples 78.4% were CEC positive. Eleven patients were monitored during their menstrual cycle and CEC tested in different phases, being the early post-ovulatory period in which the...
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Hemarthrosis in hemophilia: new treatment methods and the effect of hemarthroses repetition on joints sensitivity
Teyssler, Petr ; Bobek, Vladimír (advisor) ; Jahoda, David (referee) ; Komrska, Vladimír (referee)
Intraarticular bleeding is a complication, that concerns almost every person with haemophilia. The number and heaviness of them depends on the grade of illness and on presence of inhibitor. Presence of blood inside joint cavity leads to destruction of joint cartilage and haemophilic artropathy occures. Consequent events are as follows: bleeding - synovial irritation - re-bleeding - chronic haemophilic synovitis - haemophilic artropathy. There are four main targets of this work: 1. to summarize the possibilities of treatment of chronic haemophilic artropathy with radionuclides and to rise indication criteria for that kind of treatment, 2. to evaluace retrospectively long term efficacy od radiation synovectomy with corelation to other methods of treatment, 3. to find out, if platelet-rich-plasma therapy is effective in chronic haemophilic artropathy and 4. to find out, what is the effect of repeated intraarticular bleedings on joints sensitivity. 4 hypothesis are pronounced and methodology of their confirmation or disprove is described. There are results presented of prospective study of radiation synovectomy including recommendation of treatment indication. Further, this method is compared to other ones, from the point of view of the long term efficacy in retrospective study. Beneficial effect of...
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Hemarthrosis in hemophilia: new treatment methods and the effect of hemarthroses repetition on joints sensitivity
Teyssler, Petr ; Bobek, Vladimír (advisor) ; Jahoda, David (referee) ; Komrska, Vladimír (referee)
Intraarticular bleeding is a complication, that concerns almost every person with haemophilia. The number and heaviness of them depends on the grade of illness and on presence of inhibitor. Presence of blood inside joint cavity leads to destruction of joint cartilage and haemophilic artropathy occures. Consequent events are as follows: bleeding - synovial irritation - re-bleeding - chronic haemophilic synovitis - haemophilic artropathy. There are four main targets of this work: 1. to summarize the possibilities of treatment of chronic haemophilic artropathy with radionuclides and to rise indication criteria for that kind of treatment, 2. to evaluace retrospectively long term efficacy od radiation synovectomy with corelation to other methods of treatment, 3. to find out, if platelet-rich-plasma therapy is effective in chronic haemophilic artropathy and 4. to find out, what is the effect of repeated intraarticular bleedings on joints sensitivity. 4 hypothesis are pronounced and methodology of their confirmation or disprove is described. There are results presented of prospective study of radiation synovectomy including recommendation of treatment indication. Further, this method is compared to other ones, from the point of view of the long term efficacy in retrospective study. Beneficial effect of...
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