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Standardized Study of Skin Permeation of Caffeine from Creams with Transkarbam 12
Štiková, Jana ; Doležal, Pavel (advisor) ; Vachek, Josef (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of Pharmaceutical Technology Candidate Mgr. Jana Štiková Consultant Doc. RNDr. Pavel Doležal, CSc. Title of Thesis Standardized study of skin permeation of caffeine from creams with transkarbam 12 The teoretical part of this work covers topics of permeability of skin barrier and transdermal drug application. It briefly summarizes existing knowledge about transdermal permeation enhancers, particularly transkarbams. It also deals with in vitro tests and dermal electrical resistance measurement. The aim of this work was to gain data for documentation and testing of the existence of the connection between the transdermal electrical resistance and the flux of caffeine as chosen permeant from suspensions and from creams containing transkarbam 12. The subsequent aim was to verify if better (more interpretable) results in in vitro permeation measurements can be acquired by correction of the values of caffeine flux from cream by immediately preceding measurement of its flux from suspension. The higher the skin conductivity, the higher the caffeine permeation from donor symplex was recorded. The following correlation coefficients of logarithmic approximation of relationship between permeant fluxes and skin electrical...
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Origin of species by interspecific hybridization in animals
Štiková, Jana ; Reifová, Radka (advisor) ; Choleva, Lukáš (referee)
Speciation mostly occur by splitting an ancestral species into two daughter species. Alternatively, new species may arise by hybridization, a phenomenon known as hybrid speciation. This type of speciation is frequent especially in plants, but recently, a growing number of example has been described also in animals. The aim of this thesis is to summarize the current knowledge about hybrid speciation and describe known examples of hybrid speciation in animals. Hybrid speciation in animals is mostly homoploid, e.g. without the change of number of chromosomes. I found 23 homoploid hybrid species in animals. Most of them belong to insects and fishes, but know examples are also among birds and mammals. Origin of species in animals by hybrid speciation seems to be more commons than was previously thought. Powered by TCPDF (www.tcpdf.org)
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Standardized Study of Skin Permeation of Caffeine from Creams with Transkarbam 12
Štiková, Jana ; Doležal, Pavel (advisor) ; Vachek, Josef (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of Pharmaceutical Technology Candidate Mgr. Jana Štiková Consultant Doc. RNDr. Pavel Doležal, CSc. Title of Thesis Standardized study of skin permeation of caffeine from creams with transkarbam 12 The teoretical part of this work covers topics of permeability of skin barrier and transdermal drug application. It briefly summarizes existing knowledge about transdermal permeation enhancers, particularly transkarbams. It also deals with in vitro tests and dermal electrical resistance measurement. The aim of this work was to gain data for documentation and testing of the existence of the connection between the transdermal electrical resistance and the flux of caffeine as chosen permeant from suspensions and from creams containing transkarbam 12. The subsequent aim was to verify if better (more interpretable) results in in vitro permeation measurements can be acquired by correction of the values of caffeine flux from cream by immediately preceding measurement of its flux from suspension. The higher the skin conductivity, the higher the caffeine permeation from donor symplex was recorded. The following correlation coefficients of logarithmic approximation of relationship between permeant fluxes and skin electrical...
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Transkarbam 12 and caffeine transdermal permeation from oleocreams. 1.
Štiková, Jana ; Berka, Pavel (advisor) ; Doležal, Pavel (referee)
The transdermal application of active substances and the related topic - skin barrier permeability were reviewed in theoretical part of this work. Present knowledge in transdermal permeation enhancers was then summarized shortly, with emphasis on Transkarbams and their development on the Faculty of Pharmacy of the Charles University. The results of the in vitro permeation experiments through full thickness pig ear skin are presented in the following experimental part. The acceleration effect of various concentrations of Transkarbam 12 (T12) on caffeine permeation from oleocreams containing 60% aqueous phase is evaluated. The following values of mean fluxes of caffeine Jr were found 7,88 ± 1,52 g.cm-2 .h-1 ; 9,34 ± 1,62 g.cm-2 .h-1 ; 10,89 ± 2,03 g.cm-2 .h-1 ; 11,29 ± 3,03 g.cm-2 .h-1 and 11,09 ± 2,21 g.cm-2 .h-1 for creams containing from creams containing 0%; 0,3%; 0,5%; 0,7% and 1% T12, respectively. Keywords: transdermal administration of active substances, skin barrier, transdermal permeation enhancers, Transkarbam 12.
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