|
|
Metabolic and structural differences in primary aldosteronism and essential hypertension
Šomlóová, Zuzana ; Widimský, Jiří (advisor) ; Mlíková Seidlerová, Jitka (referee) ; Červenka, Luděk (referee)
Hypertension is a major risk factor for cardiovascular (CV) disease, and patients with primary aldosteronism (PA) - the most common endocrine cause of hypertension - have a higher incidence of CV complications. The aim of this study was to evaluate the incidence of metabolic differences and organ complications - kidney, heart and blood vessels damage in patients with essential hypertension (EH), PA and its most common forms - idiopathic hyperaldosteronism (IHA) and aldosterone-producing adenoma (APA). We found a higher incidence of metabolic syndrome and a higher incidence of metabolic abnormalities in IHA compared to APA - higher prevalence of metabolic syndrome, higher levels of triglycerides and lower levels of HDL cholesterol and thereby a higher cardiometabolic risk. Metabolic profile of patients with IHA is similar to EH in contrast to APA. Arterial stiffness was expressed as pulse wave velocity (PWV), in central arteries as carotid-femoral PWV and at peripheral level as femoral-ankle PWV. Patients with PA with comparable levels of blood pressure (BP) have higher stiffness of central elastic and peripheral muscular arteries than patients with EH. The main predictor of impaired peripheral arterial stiffness is the plasma aldosterone level. Patients with IHA have higher central arterial...
|
|
|
The influence of dietary therapy on insulin resistance in obese persons
Šomlóová, Zuzana ; Štich, Vladimír (advisor)
Obesity is accompanied mankind throughout its existence, we have evidence of it has to prehistoric times. People have had enough physical activity and had little energy intake , therefore , the incidence of obesity rather rare. Although obesity has been well is an individual problem , more and more perceived as a serious and growing social health problem. Increased weight proved predisposing factor for various diseases, particularly cardiovascular diseases, diabetes mellitus Type 2 diabetes , sleep apnea , osteoarthritis , colorectal cancer and other tumors . It increases insulin resistance , which is a precursor of diabetes mellitus. It is part of metabolic syndrome , along with changes in lipid levels , increased blood pressure and insulin resistance . Despite the widespread access to information on nutrition in schools , in hospitals and on the Internet , overeating remains a major problem . according to data WHO , the average daily per capita calorie intake of 9660 kJ in 1963 to 10 250 kJ in 1971 and 11 420 kJ in 1992. estimated to be energy intake in 2010 increased to 12,200 kJ . Between 1977 and 1995, fourfold increased calorie intake and income tripled energy-rich foods from fast food . Obesity and overweight are becoming a global epidemic and therefore we need more focus on the prevention of obesity...
|
guest ::
