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Set of worksheets for the exhibition "Haptic models for people with disabilities"
ŠÍPOVÁ, Hana
The diploma thesis deals with the creation of a set of worksheets dedicated to the exhibition of haptic models, which are located in the Dominican monastery in České Budějovice. The thesis consists of theoretical and project part. The first part mentioned above deals with the history of the monastery from an architectonic and cultural point of view. Furthermore, individual haptic models are processed both from a historical and descriptive point of view. The thesis also takes into consideration the methodology of creating haptic models for the blind. The last chapter of the theoretical part is focused on museum education as a medium of mediating art to visitors, through self-service worksheets for lower secondary school pupils. It also includes a brief description of the above-mentioned age category. The project part is focused on creating worksheets, including their trial evaluation in the church and the adjacent cloister of the monastery. Its subsequent reflection is also taken into account.
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Study of Biomolecular Interactions with Surface Plasmon Resonance Biosensors
Šípová, Hana ; Homola, Jiří (advisor) ; Houska, Milan (referee) ; Skládal, Petr (referee)
Surface plasmon resonance (SPR) biosensors represent one of the most advanced sensing technologies for real-time studies of biomolecular interactions. In this thesis, methods for functionalization of SPR substrates were optimized and studied via spectroscopic methods. Effects related to the SPR sensor microfluidic interface on the measured biomolecular interactions were analyzed, and furthermore, means to decrease mass-transport limitations were proposed. Several SPR-based assays regarding the detection of nucleic acids were developed, which allow for the detection of physiologically relevant concentrations of nucleic acids as well as point mutations in a nucleic acid sequence. Assays for the determination of the enzymatic activity of HIV integrase and ribonuclease H were developed. These assays can be employed for the design and synthesis of molecules that function either as antiviral drugs or as gene-regulating agents.
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Educational project for village Březina in the microregion Radnice near Rokycany
ŠÍPOVÁ, Hana
The bachelor thesis deals with introdution of monuments in Březina village in microregion Radnicko near Rokycany and their promotion trough the workbook dedicated to older school age children Theoretical part deals with the noble family Sternberg and a Kašpar Maria earl Sternberg important personality of this aristocratic family. In the next part there are described individual monuments of this area and next part is dedicated to museum as an institution focused on propagation of cultural and historical heritage of the nation. In the next part of the theoretical essay there is described the workbook as a functional instrument of museum's education. Than there is the older school age specified as a target group for project part of the thesis. The project part is devoted to creation of the workbook and his consecutive analysis.
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Study of Biomolecular Interactions with Surface Plasmon Resonance Biosensors
Šípová, Hana ; Homola, Jiří (advisor) ; Houska, Milan (referee) ; Skládal, Petr (referee)
Surface plasmon resonance (SPR) biosensors represent one of the most advanced sensing technologies for real-time studies of biomolecular interactions. In this thesis, methods for functionalization of SPR substrates were optimized and studied via spectroscopic methods. Effects related to the SPR sensor microfluidic interface on the measured biomolecular interactions were analyzed, and furthermore, means to decrease mass-transport limitations were proposed. Several SPR-based assays regarding the detection of nucleic acids were developed, which allow for the detection of physiologically relevant concentrations of nucleic acids as well as point mutations in a nucleic acid sequence. Assays for the determination of the enzymatic activity of HIV integrase and ribonuclease H were developed. These assays can be employed for the design and synthesis of molecules that function either as antiviral drugs or as gene-regulating agents.
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