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Peroxisomes and their role in energetic metabolism of the heart
Čejková, Denisa ; Kolář, David (advisor) ; Horníková, Daniela (referee)
Peroxisomes are small eucaryotic organelles, mainly known for their ability to create and break down hydrogen peroxide. However their enzymes play other significant roles, they participate in beta-oxidation of fatty acids with very long or branched chains, through alpha-oxidation they enable to process molecules that cannot go through beta- oxidation cycle, they also participate in early steps of synthesis of ether-lipid or bile acides. Above mentioned aspects make peroxisomes potentionally interesting for their possible influence on heart muscle metabolism, that is dependent on oxidative degradation of fatty acids, although not very much is known about this issue. The thesis focuses on biogenesis and function of peroxisomes, but also on their possible role in heart muscle metabolism.
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Meeting the needs of patients with chronic obstructive pulmonary disease
Čejková, Denisa ; Tomová, Šárka (advisor) ; Křivková, Jana (referee)
The intention of the thesis was based on an exploratory investigation to determine whether the needs of patients with COPD varies depending on the stage of the disease. The work is divided into theoretical and empirical part. The theoretical part is divided into three chapters. The first slew characteristic of COPD, its diagnosis and subsequent treatment. The second deals with the classification of needs, motives and consequences that arise for patients insufficient meet the needs. The third part focuses on the specifics of treating patients with COPD. In the empirical part presents the results of quantitative research, which was conducted via questionnaire. Questionnaires were distributed to hospitalized patients with chronic obstructive pulmonary disease in stage II, III and IV on the second clinic of Pneumology, University Hospital Motol. Exploratory survey was conducted anonymously, from July to December 2017. The main criterion for selection of respondents were diagnosed with COPD, good physical condition, mental well-being and willingness of patients to share their feelings. A total of 76 patients were approached, of which three savings would not participate. From the exploratory investigation showed that patients II. stages are distinctly identified needs, than patients in stage III and IV....
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