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Diagnostics of Hodgkin's lymphoma
Gabriel, Kamila ; Nachtigal, Petr (advisor) ; Němečková, Ivana (referee)
AUTHOR Kamila Gabriel TITLE Diagnosis of Hodgkin's lymphoma DEPARTMENT Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences SUPERVISOR prof. PharmDr. Petr Nachtigal, Ph.D. ABSTRACT In 2015, almost three thousand of new cases of leukemias and lymphomas were reported and 1751 patients died from these cancers in the Czech Republic. Out of these, 277 cases (9 %) and 60 deaths (3.5 %) were related to Hodgkin's lymphoma (HL). In Hodgkin's lymphoma the tumor cells comprise only a small minority of the involved tissue. Two distinct groups of HL are recognized: Classical Hodgkin's Lymphoma (CHL), further divided into four subtypes, and Nodular Lymphocyte-Predominant Hodgkin's Lymphoma (NLPHL). CHL affects primarily cervical lymph nodes of young adults and may spread to other sites. The prognosis is very good with 80-90 % of patients being cured by radiotherapy and multiagent chemotherapy. However, these patients are at a significant risk of secondary malignancies. NLPHL, which constitutes about 5 % of HL, affects primarily cervical and axillary lymph nodes of patients between 30 and 40 years of age. Usually, the progression is slow and the tumor shows excellent sensitivity to therapy. When a suspicion of lymphoproliferative disease arises it is recommended...

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