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Optimizing and Evaluating the Biocompatibility of Fiber Composites with CaP Additives
Suchý, Tomáš ; Sucharda, Zbyněk ; Balík, Karel ; Sochor, M. ; Bačáková, Lucie
Composite materials based on a polyamide fabric (aramid) and a polydymethyl-siloxane (PDMS) matrix were designed for application in bone surgery. In order to increase the bioactivity, 2, 5, 10, 15, 20 and 25 vol. % of nano/micro hydroxyapatite (HA) and tricalcium phosphate (TCP) were added. The effect of the additives on the biocompatibility was studied. It appears that nano additives have a more favorable effect than micro particles on mechanical properties. For final application of the composites as substitutes for bone tissues, 15 vol. % of nano hydroxyapatite additives is an optimum amount: in this case both the mechanical properties and the biological properties are optimized without distinct changes in the inner structure of the composite.
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Carbon nanoparticles as promising components of materials for bone tissue engineering
Grausová, Ľubica ; Bačáková, Lucie (vedoucí práce) ; Mikšík, Ivan (oponent) ; Balík, Karel (oponent)
Souhrn Nanotechnologie v tkáňovém inŽenýrství se stala v posledních letech důleŽiýmpředrnětern výzkumu Pro regeneraci tkání se studují různét1p1 nanostrukturovaných materiálů. Důvodem vyuŽití těchto rnateriálťr v tkáňovém inŽenýrství je jejich schopnost napodobovat přirozenou extracelu|ární matrix a tímpodporovat adhezi, růst a diferenciaci buněk. Náš ýzkum by| zaměřen na v|iv vrstev fullerenů, kompozitů uh|íkoqýclr nanotub a syntetického terpolymeru a vrstev rranokrystalického diamantu na adhezi, růst,životaschopnost a diferenciaci lidských osteoblastů linie MG 63. KaŽdý z těchto materiálů podporoval kolonizaci svého povrclru buňkami. Na kontirruálrrích vrstvách fu1lerenů Coo, deponovanýclr na uhlíkové kompozity s uhlíkovou matricí vyáuženou uhlíkovými vlákny byla sice populačníhustota buněk nižšív porovnání s uhlíkov'ým kompozitem bez fullerennílro filmu, ale tyto buriky dosahovaly větší adhesní plochy, coŽ bylo dale spojeno s dobře q'vinuým beta- aktinov'ým cýoskeletem a foká|ními adhezními plaky s obsahem vinkulinu. Na kompozitech uhlíkových nanotub a terpolymeru složenélioz po|ýetrafluoroeýlenu, po|ypropylenu a poly.viny|difluoridu' byla adhese buněk, jejich rozprostření, tvorba fokálníclr adlresních plakůa aktinového cytoskeletu, viabilita a buněčnýrůstznačnězlepšena v porovnání s čisýmterpolymerem....
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Particulate composites based on nano HA/TCP particles for bone graft replacements
Suchý, Tomáš ; Rýglová, Šárka ; Balík, Karel ; Sucharda, Zbyněk ; Denk, F.
Particulate composite materials have been developed for applications in the form of an intervertebral cage (for use in spine treatment). The intervertebral cage is composed of a bearing cage made of PEEK and a composite core with the surface contacting the bone surface and ensuring elastic linkage of two vertebral bodies, resulting in good adhesion to the bone. Mechanical analysis of different kinds of particulate composites was performed. The effect of hydroxyapatite and tri-calcium phosphate nanofiller volume fractions on the mechanical properties of particulate composites was investigated.
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Biocompatibility optimization of fabric composites by calcium phosphates
Sochor, M. ; Balík, Karel ; Suchý, Tomáš ; Sucharda, Zbyněk
Composite materials based on a polyamide fabric and a polydimethylsiloxane matrix were designed for application in bone surgery. In order to increase the bioactivity, 2, 5, 10, 15, 20 and 25 vol. % of nano/micro hydroxyapatite and tricalcium phosphate were added. The effect of the additives on the mechanical properties was studied. Simultaneously, changes in the inner structure of the composites were investigated by means of image analysis.
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Some surface improvement and osseointegration
Suchý, T. ; Balík, Karel ; Sedláček, R. ; Sochor, M.
As a further perspective material to be used in orthopedics, glass fibers (R-glass, 21055 satin-woven fabric, VETROTEX, Saint Gobain, France) and polysiloxane matrix (M130, Lučební závody Kolín, Czech Republic) based composite materials have been investigated.
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