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Molecular aspects of genetic predisposition to type 2 diabetes mellitus and its monogenic forms
Pintérová, Daniela ; Černá, Marie (advisor) ; Bendlová, Běla (referee) ; Hubáček, Jaroslav (referee)
The aim of this work was to study some molecular aspects of genetic predisposition to T2DM and its monogenic forms. We searched for correlations of genotypes with many clinical and laboratory markers and tried to evaluate their significance. The consequences for possible changes in the treatment some particular patients were under discussion. Especially for those suffering from monogenic forms we were able to reach better compensation of DM, or at latest the same compensation for more acceptable therapy. We studied the associations of chosen candidate genes, PPAR, NF-B, its inhibitor IB, known polymorphisms and T2DM including diabetic complications. We used the association study approach to find out if there is any association between available genetic variants among our patients and T2DM with its phenotypic abnormalities (changed levels of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides, further the presence of diabetic complications).
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Molecular aspects of genetic predisposition to type 2 diabetes mellitus and its monogenic forms
Pintérová, Daniela ; Černá, Marie (advisor) ; Bendlová, Běla (referee) ; Hubáček, Jaroslav (referee)
The aim of this work was to study some molecular aspects of genetic predisposition to T2DM and its monogenic forms. We searched for correlations of genotypes with many clinical and laboratory markers and tried to evaluate their significance. The consequences for possible changes in the treatment some particular patients were under discussion. Especially for those suffering from monogenic forms we were able to reach better compensation of DM, or at latest the same compensation for more acceptable therapy. We studied the associations of chosen candidate genes, PPAR, NF-B, its inhibitor IB, known polymorphisms and T2DM including diabetic complications. We used the association study approach to find out if there is any association between available genetic variants among our patients and T2DM with its phenotypic abnormalities (changed levels of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides, further the presence of diabetic complications).
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Small business risk analysis
PINTEROVÁ, Daniela
This thesis is focused on small firms in region of Prachatice and analysing their business risks. There is discription of the state of small and medium-sized enterprises and a brief summary of the risks that affect these companies. The thesis describes situation in South Bohemia, particulary Prachatice region and compares particular South Bohemian regions. Aforementioned research uses questionnaires as a main method, both in the form of personal interviews, as well as in electronic form. There is an obvious conclusion from that research, that the companies are well aware of risks and see them as a threat to their future goals they want to achieve. Diversification and risk shifting are most common instruments to avoid or at lest mitigate those dangers. Companies participating in the survey are most concerned about the business and financial risks. On the other hand, industrial risks are not percieved as significant problem. Among other precautions leasing to reduction of risks is mutual and timely communication betweeen company branches, consideration of indicators in general. Each employee should be aware of the risks associated with his work. Enterprises with a elaborate approach to risk are becoming more competitive, stable and more resilient to external negative influences.
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