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Estimation of Company Value
Kuběnová, Markéta ; Kazda, Pavel (referee) ; Kocmanová, Alena (advisor)
The subject of this master‘s thesis is to analyze the value of a company using method called discounted cash flow and economic value added. As for the structure, the thesis is divided in two main parts – theoretical and practical. In the theoretical one the most important concepts, principles and methods are presented. Practical part is focused on analyses, which have to be used as a tool to specify a value of a company. The result of the thesis is the measuring of a company’s value at the date of its valuation.
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Haemonchus contortus - metabolism of anthelmintics and other model xenobiotics in vitro
Kuběnová, Markéta ; Skálová, Lenka (advisor) ; Lamka, Jiří (referee)
Most economic losses in ruminant are associated with gastrointestinal parasite infections. Haemonchus contortus is one of the most pathogenic parasites of small ruminants (sheep, goat). H. contortus exhibits considerable adaptability to unfavourable conditions and its occurrence is world-wide. Today, the treatment of haemonchosis is complicated due to resistance of H. contortus to common anthelmintics, especially those with benzimidazole structure. Biotransformation enzymes, that protect parasite against toxic effect of anthelmintics, may contribute to development of resistance. The aim of this project was to study the biotransformation of benzimidazole anthelmintic flubendazole in H. contortus and to find out biotransformation of other model xenobiotics. The results showed that cytosolic NADPH-dependent enzymes of H. contortus deactivate flubendazole via reduction of its carbonyl group. Substantial reduction of other xenobiotics was also found. Significant activity of glutathion S- tranferases may aid to anthelmintics further deactivation. The new information about biotransformation enzymes of parasites contribute to understanding of mechanism of resistance.
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Haemonchus contortus - metabolism of anthelmintics and other model xenobiotics in vitro
Kuběnová, Markéta ; Skálová, Lenka (advisor) ; Lamka, Jiří (referee)
Most economic losses in ruminant are associated with gastrointestinal parasite infections. Haemonchus contortus is one of the most pathogenic parasites of small ruminants (sheep, goat). H. contortus exhibits considerable adaptability to unfavourable conditions and its occurrence is world-wide. Today, the treatment of haemonchosis is complicated due to resistance of H. contortus to common anthelmintics, especially those with benzimidazole structure. Biotransformation enzymes, that protect parasite against toxic effect of anthelmintics, may contribute to development of resistance. The aim of this project was to study the biotransformation of benzimidazole anthelmintic flubendazole in H. contortus and to find out biotransformation of other model xenobiotics. The results showed that cytosolic NADPH-dependent enzymes of H. contortus deactivate flubendazole via reduction of its carbonyl group. Substantial reduction of other xenobiotics was also found. Significant activity of glutathion S- tranferases may aid to anthelmintics further deactivation. The new information about biotransformation enzymes of parasites contribute to understanding of mechanism of resistance.
|
|
|
Estimation of Company Value
Kuběnová, Markéta ; Kazda, Pavel (referee) ; Kocmanová, Alena (advisor)
The subject of this master‘s thesis is to analyze the value of a company using method called discounted cash flow and economic value added. As for the structure, the thesis is divided in two main parts – theoretical and practical. In the theoretical one the most important concepts, principles and methods are presented. Practical part is focused on analyses, which have to be used as a tool to specify a value of a company. The result of the thesis is the measuring of a company’s value at the date of its valuation.
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