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Acyclovir release from plasticized oligoesters
Hlavsová, Lucie ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
Hlavsová Lucie: Acyclovir release from plasticized oligoesters. Diploma thesis. Faculty of Pharmacy in Hradec Králové, 2008. Summary The aim of this work was the study of the Acyclovir release from oligoester carriers branched with various concentration of either mannitol (3M, 5M, 8M) or dipentaerythritol (3D, 5D, 8D) and plasticized with 30 % triethyl citrate (TEC) or 20 % ethyl pyruvate (EP). Theoretical part is occupied with physical-chemical properties of the lactic-glycolic polyesters, biodegradation and formation of the stereo complexes. It is also directed at the herpetic viruses, properties of ACV and other virostatics. The 150,0 mg matrices composed of carrier, Acyclovir of 4% and plasticizer either TEC of 30% or EP of 20% were prepared. They were put to the static dissolution test using phosphate citrate buffer pH 6,0 at 37řC. The ACV released was determined spectrophotometricaly at 256 nm. The best release behaviour was found at the carrier 3M with the linear ACV released during 20 day. Significant acceleration at the 6th hour going on to the 1st day was observed.
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Acyclovir release from plasticized oligoesters
Hlavsová, Lucie ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
Hlavsová Lucie: Acyclovir release from plasticized oligoesters. Diploma thesis. Faculty of Pharmacy in Hradec Králové, 2008. Summary The aim of this work was the study of the Acyclovir release from oligoester carriers branched with various concentration of either mannitol (3M, 5M, 8M) or dipentaerythritol (3D, 5D, 8D) and plasticized with 30 % triethyl citrate (TEC) or 20 % ethyl pyruvate (EP). Theoretical part is occupied with physical-chemical properties of the lactic-glycolic polyesters, biodegradation and formation of the stereo complexes. It is also directed at the herpetic viruses, properties of ACV and other virostatics. The 150,0 mg matrices composed of carrier, Acyclovir of 4% and plasticizer either TEC of 30% or EP of 20% were prepared. They were put to the static dissolution test using phosphate citrate buffer pH 6,0 at 37řC. The ACV released was determined spectrophotometricaly at 256 nm. The best release behaviour was found at the carrier 3M with the linear ACV released during 20 day. Significant acceleration at the 6th hour going on to the 1st day was observed.
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Branched Oligoesters Plasticized Using Methylsalicylate as Carriers of Drugs
Hlavsová, Lucie ; Dittrich, Milan (referee) ; Šnejdrová, Eva (advisor)
Hlavsová, L.: Branched oligoesters plasticized using methylsalicylate as carriers of drugs Summary The aim of this work was to study acyclovir release from plasticized oligoester matrices. Tested matrices are branched terpolymers of D,L-lactic acid, glycolic acid and mannitol or dipentaerythritol. Carriers were plasticized using 10%, 20% or 30% of methyl salicylate. Theoretical part is concerned with synthesis, degradation and application of polyesters, drug release from polymers, infections caused by herpetic viruses and antivirotics. Within the experimental part of this work 150,0 mg matrices by method of melting of carriers together with plasticizer at temperature less than 80řC was prepared. In addition to matrices with drug the matrices without drug (placebo) were prepared. The static dissolution test was done using phosphate citric buffer pH 6,0 at temperature of 37řC. The absorbation of the dissolution liquid at given intervals was measured at wave length 256 nm against both the buffer and placebo dissolution liquid. Drug release was influenced first of all by the properties of oligoester carrier, minor by plasticizer concentration in matrices. The elution of the methyl salicylate was arisen at the beginning of the dissolution, so there is no plasticizer in the system in the later phases of the...
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