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Strategic Analysis of Company GZ Media, Inc.
Velková, Martina ; Boukal, Petr (advisor) ; Špička, Jindřich (referee)
The content of this Bachelor Thesis is the strategic Analysis and partial steps in the company GZ Media, Inc. From 2011 to 2016, which operates on the market with vinyl record music and another music media. The aim is to provide the reader with a summary of the analyzed company and the industry in which the company operates. The work is divided into two parts, the theoretical and the practical. The theoretical part describes all the methods and tools that are needed for the Analysis itself. Attention is focused on the macro and micro environment of enterprise, Analysis of internal resources and financial Analysis. At the end, comprehensive SWOT Analysis and definition of corporate strategy. The practical part is already focused on the application of different methods on specific company and industry. The practical part aim is to bring the investigated part of the industry.
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Laboratory diagnosis of mycobacteria, with a focus on the bacteriological proof
VELKOVÁ, Martina
Laboratory methods play an important role in disease diagnostic. Although there are currently available fast molecular genetic methods and methods based on cell response, basic diagnostic method of direct evidence is still microscopy and cultivation. Microscopy (staining by Ziehl-Neelsen and fluorescence microscopy) is the primary method for most of the specimens, especially for sputum. The sensitivity of this method is not very high because for the detection of a positive finding in 1 mm3 is needed at least 105 microbes. However, the method is important because it can fastly proof extensive clinical and epidemiological serious diseases. The ?Golden standard? is today the cultivation on solid egg media. Nowadays it is filled in automatic detection system, which accelerates the time of detection. The thesis was carried out in the Laboratory of Medical Microbiology, Bacteriology department, Hospital Ceske Budejovice in the period from 1.1.2013 till 6.6.2013, and included 400 sputa, which were processed and examined. The purpose was to compare the effectiveness of decontamination methods with HCl and with NALC, and to monitor the recovery and detection for the automatic detection system and conventional cultivation. In the automatic system using the BACTECTM MGITTM 960 Non-Radiometric fluorescent technology is cultivation in liquid Middlebrook 7H9 medium supplemented with antimicrobials (polymyxin B, amphotericin B, nalidixic acid, trimethoprim, azlocilin). The classical culture used solid egg culture medium: Lowenstein-Jensen and culture medium by Ogawa. The individual results then show that the method of HCl had the overall contamination of 1 % of the samples. For each methods in 5 % BACTECTM MGITTM 960 and 4 % in the conventional cultivation. In comparison the method NALC, had the overall contamination of 21 % of the samples. For the individual methods in 26 % of BACTECTM MGITTM 960 and 50 % in the conventional cultivation. From these results it is obvious that the method with the NALC has lower efficiency, the proportion of contamination compared to the method with HCL increased by 20 %. Decontamination with the NALC method recommended by the manufacturer for BACTECTM MGITTM 960 was found to be unsatisfactory and was canceled. Comparing the recovery and the detection of the strains isolated in individual methods showed that the BACTECTM MGITTM 960 exhibits greater sensitivity than conventional cultivation, since the total of 17 strains isolated BACTECTM MGITTM 960 captured 15 against 10 strains isolated in conventional cultivation. There is also a significantly shorter time to detect positive samples. The average detection time for BACTECTM MGITTM 960 was 16.2 days, while a conventional culturing was 31 days. It was confirmed that the BACTECTM MGITTM 960 system achieves better results, but optimization is achieved by combining the two methods used. There is an apparent decrease in detection of mycobacteria from the processed statistical data of the strains isolated during the period 2010 - 2012, but a substantial reduction does not occur. Noticeable is only the decline of the isolated stains of Mycobacterium bovis BCG, which can be explained by the fact that the vaccination against tuberculosis is since 2011 no longer carried out across the board, but according to the new legislation in force only in high-risk groups. An interesting fact is that every year the highest laboratory detection is found in the age group of over 60 years.
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Hyperactivity
VELKOVÁ, Martina
In my diploma thesis I deal with the issues of hyperactivity that has recently been a very current and discussed topic. In the theoretic part of my thesis, I specify the concept of hyperactivity and talk further about its symptoms and consequent effects. I, as well, pay close attention to the current possibilities of reeducation with a consequent focus on the programs supporting hyperactive children and their parents. The practical part of the diploma thesis consists of three parts: an interview with a pedagogue working with hyperactive children; a case report of a hyperactive child; questionnaire survey and its subsequent interpretation. The practical part of the diploma thesis focuses on the particular symptoms of hyperactivity at hyperactive children in the school environment and their consequent effects. It tries to find out the possibilities of the reeducation and remedy at the same time. In detail, it targets the help to hyperactive children and their parents offered by schools and consequently the ratio of utilization by the parents. At the very end of the practical part of the diploma thesis, I dedicate my work to an assessment of hypothesis defined by myself.
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