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The use of Turbula® mixer in homogenization of a mixture of drug with the AmylFarm® filler for the preparation of oral powders in Pharmacy
Kadlecová, Romana ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Mentor: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: PharmDr. Sylva Klovrzová, Ph.D. Student: Mgr. Romana Kadlecová Title od Thesis: The use of Turbula® mixer in homogenization of a mixture of drug with the AmylFarm® filler for the preparation of oral powders in Pharmacy In this experimental work, the influence of container loading and homogenization time on the content uniformity of divided oral powders mixed in a Turbula T2F mixer was investigated. The speed of mixer 49 rpm was constant. The powder mixtures containing 20 mg of the active substance propranolol-hydrochloride in the AmylFarm filler were prepared in three volumes 37 ml, 74 ml and 111 ml, corresponding to the 100, 200 and 300 capsules, respectively. The results were compared with the conventional mixing using a mortar and pestle. The insignificant difference in homogeneity of mixtures prepared by both methods was proved. The optimum mixing time in a rotary mixer was 10 minutes for a 37 ml mixture, and 15 minutes for the larger mixture volumes 74 and 111 ml.
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Adhesivity of in situ PLGA films for the local drug delivery.
Paňkiv, Julie ; Šnejdrová, Eva (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Mentor: PharmDr. Eva Šnejdrová, Ph.D. Consultant: PharmDr. Věříš Andrea Student: Julie Paňkiv Title of Thesis: Adhesivity of in situ PLGA films for the local drug delivery The goal of this work was the formulation and study of the film forming systems FFS formed by poly(lactic-co-glycolic) acid of linear or branched structure, plasticized with methyl- salicylate, ethyl-pyruvate or ectoine, with incorporated cannabidiol. Acetone and ethyl acetate were tested as solvents. The theoretical part is focused on the characterization of FFS, their composition and testing. In situ films were characterized by DSC and SEM. The course of evaporation of the organic solvent from the FFS was monitored. A methodology for testing adhesion of in situ films using a tensile test on a rheometer was developed. It was found that the evaporation time of the organic solvent from FFS is influenced by both the type of solvent used and the type of plasticizer. In non-plasticized polymers, organic solvent evaporates faster than in plasticized ones. Evaporation of more than 90 % of the solvent occurs within 5 minutes. Compared to the commercial preparation Lamisil Once, the tested PLGA in situ films show higher adhesiveness....
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Adhesivity of in situ PLGA films for the local drug delivery.
Paňkiv, Julie ; Šnejdrová, Eva (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Mentor: PharmDr. Eva Šnejdrová, Ph.D. Consultant: PharmDr. Věříš Andrea Student: Julie Paňkiv Title of Thesis: Adhesivity of in situ PLGA films for the local drug delivery The goal of this work was the formulation and study of the film forming systems FFS formed by poly(lactic-co-glycolic) acid of linear or branched structure, plasticized with methyl- salicylate, ethyl-pyruvate or ectoine, with incorporated cannabidiol. Acetone and ethyl acetate were tested as solvents. The theoretical part is focused on the characterization of FFS, their composition and testing. In situ films were characterized by DSC and SEM. The course of evaporation of the organic solvent from the FFS was monitored. A methodology for testing adhesion of in situ films using a tensile test on a rheometer was developed. It was found that the evaporation time of the organic solvent from FFS is influenced by both the type of solvent used and the type of plasticizer. In non-plasticized polymers, organic solvent evaporates faster than in plasticized ones. Evaporation of more than 90 % of the solvent occurs within 5 minutes. Compared to the commercial preparation Lamisil Once, the tested PLGA in situ films show higher adhesiveness....
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Study of the influence of co-processed dry binder type on the properties of orally disintegrating tablets with antihypertensives.
Martiníková, Lenka ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Mentor: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Student: Lenka Martiníková Title of Thesis: A study of the influence of co-processed dry binder type on the properties of orally disintegrating tablets with antihypertensives. This thesis deals with the study of tableting materials and orally dispersible tablets containing coprocessed dry binders Ludiflash® , Prosolv® ODT G2 and Parteck® ODT in combination with the antihypertensives ramipril and perindopril. The tablets also contained the sweetener sucralose and the lubricant magnesium stearate in a concentration of 1%. The tablets were compressed at a compression force of 3 kN. The evaluated parameters were the energy profile of the compression process, tablet tensile strength, friability, disintegration time, wetting time, water absorption and tablet porosity. The highest values of the total compression energy showed tablets containing Ludiflash® in combination with perindopril and the lowest values had tablets containing Prosolv® ODT G2 with ramipril. Tablets from the combination of Parteck® ODT with ramipril and Ludiflash® with perindopril showed the highest tensile strength of the tablets. Conversely, tablets from Prosolv® ODT G2 with both drugs...
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Study of tableting materials and tablets from spray-dried mixtures of the drug and excipients
Prejdová, Magdaléna ; Mužíková, Jitka (advisor) ; Smékalová, Monika (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Mentor: doc. PharmDr. Jitka Mužíková, Ph.D. Conzultant: Mgr. Thao Tranová Student: Magdaléna Prejdová Title of Thesis: Study of tableting materials and tablets from spray-dried mixtures of the drug and excipients This work deals with the influence of three different size fractions of spray dried powders (SDP) on flow properties and on the compressibility of tablets. The aim was to obtain orodispersible tablets with a poorly soluble drug aprepitant. Different particle sizes were obtained by different nitrogen flow rates during spray drying. The SDP were composed of aprepitant and hypromellose phthalate in a 1:2 ratio. The structure of the SDP was tested by scanning electron microscopy. SPD were part of directly compressible tabletting materials or tabletting materials made from granulates. All tablets contained the co-processed dry binder Prosolv® ODT G2, the sweetener sucralose and the lubricant magnesium stearate. The tested parameters of powders and tabletting materials were particle size and flow properties. The tablets were compressed by material testing machine the Zwick/Roell with a compression force of 2.5 kN. The compression process was evaluated by using the energy profile of the compression...
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The preparation of tablets by selective laser sintering.
Ficek, Lukáš ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
Charles University, Faculty of pharmacy in Hradec Králové Department of: Pharmaceutical Technology Mentor: doc. PharmDr Jitka Mužíková, Ph. D Consultant: Mgr. Thao Tranová Student: Lukáš Ficek Title of Thesis: The preparation of tablets by laser sintering This work focuses on the preparation of orally dispersible tablets by selective laser sintering (SLS). The present project is a pilot study conducted on the 3D printer Sintratec Kit at the Department of Pharmaceutical Technology. SLS is a 3D printing method based on the fusion of powder particles using a laser beam that sinters the individual particles together in the layers of material.1-2 The matrix forming polymer used in work was Kollidon® VA64 which was combined with two pigments namely Candurin® Gold Sheen and NTX Ruby Red. In addition, mixtures of the polymer with a co-processed dry binder Prosolv® ODT G2 and a physical mixture of mannitol, silicified microcrystalline cellulose, and crospovidone at the concentrations of 20%, 40%, and 60% were used. The influence of printing parameters, especially laser speed, on tablet quality was tested. NTX Ruby Red pigment was selected for final tablet printing. The best powder formulation for optimal printing progress and high-quality properties of the orally dispersible tablets was the mixture of...
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Study of excipients' influence on the drug dissolution from tablets
Ouzký, Miroslav ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Supervisor: Consultants: Assoc. Prof. PharmDr. Zdeňka Šklubalová, Ph.D. Mgr. Jana Brokešová, Mgr. Daniel Pěček Student: Miroslav Ouzký Title of Thesis: Study of excipientsʼ influence on the drug dissolution from tablets The aim of this work was to study the influence of excipients on the dissolution of the high-dose active substance from tablets. The tablets were compressed from the granules prepared by wet-granulation method. 11 batches of tablets which contained two different fillers: either lactose or microcrystalline cellulose, respectively; and extragranularly added disintegrant: either croscarmellose or crospovidone, respectively, in three concentration levels of 2 %, 3,7 % or 5,4 % were prepared. Tablets were packed into aluminium/PVC blisters. The paddle dissolution test was used to determine the release of the active substance into phospate buffer pH 7,2 at the time of preparation (time 0) and at the time points 1.5, 3 and 6 months of stability assay at 40 řC and 75 % relative air humidity. The results show that the drug release from tablets containing microcrystalline celulose was generally faster than from those containing lactose. The same was true for tablets to which croscarmellose was...
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Study of excipients' influence on the drug dissolution from tablets
Ouzký, Miroslav ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Supervisor: Consultants: Assoc. Prof. PharmDr. Zdeňka Šklubalová, Ph.D. Mgr. Jana Brokešová, Mgr. Daniel Pěček Student: Miroslav Ouzký Title of Thesis: Study of excipientsʼ influence on the drug dissolution from tablets The aim of this work was to study the influence of excipients on the dissolution of the high-dose active substance from tablets. The tablets were compressed from the granules prepared by wet-granulation method. 11 batches of tablets which contained two different fillers: either lactose or microcrystalline cellulose, respectively; and extragranularly added disintegrant: either croscarmellose or crospovidone, respectively, in three concentration levels of 2 %, 3,7 % or 5,4 % were prepared. Tablets were packed into aluminium/PVC blisters. The paddle dissolution test was used to determine the release of the active substance into phospate buffer pH 7,2 at the time of preparation (time 0) and at the time points 1.5, 3 and 6 months of stability assay at 40 řC and 75 % relative air humidity. The results show that the drug release from tablets containing microcrystalline celulose was generally faster than from those containing lactose. The same was true for tablets to which croscarmellose was...
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Formulation and characterization of w/o emulsions for local treatment of musculoskeletal infections
Vedralová, Štěpánka ; Šnejdrová, Eva (advisor) ; Mužíková, Jitka (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Author: Štěpánka Vedralová Title of diploma thesis: Formulation and characterization of w/o emulsions for local treatment of musculoskeletal infections Supervisor: PharmDr. Eva Šnejdrová, Ph.D. The aim of the diploma thesis was to formulate a depot dosage form for the prevention and local treatment of musculoskeletal infections. A water-in-oil emulsions have been formulated which, due to the partition coefficient between the outer and inner phases, can provide sustained drug release. Oils with different viscosities were tested as oil phases. Tricaprin was chosen for the preparation of emulsions, due to the highest stability of the prepared emulsion. Lecithin and sorbitan monooleate or polyglyceryl-3-polyricinooleate (PGPR) and magnesium stearate were used as emulsifiers. The aqueous phase was a solution of vancomycin hydrochloride and gentamicin sulphate. The flow properties on a rotational rheometer were evaluated. The influence of the emulsion composition and the homogenization method on the coefficient of consistency and the index of flow behaviour of the emulsions was studied. The emulsions stabilized with lecithin have a higher viscosity and a structure more sensitive to changes in composition...
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A study of tableting materials and tablets with the retarding component containing hypromellose and carmellose sodium.
Koukolová, Kristýna ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Kristýna Koukolová Consultant: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of tableting materials and tablets with the retarding component containing hypromellose and carmellose sodium The thesis deals with the study of compressibility of directly compressible tableting materials containing coprocessed dry binders MicroceLac® 100 and Prosolv® SMCC 90 in combination with the retarding component CompactCel® SR, which is a mixture of hypromellose and carmellose sodium. The tested concentrations of the retarding component were 10 %, 20 % and 30 %. The formulations also contained salicylic acid as a model drug at concentration of 25 % and sodium stearyl fumarate as a lubricant at concentration of 1%. Flow properties, specifically fowability, apparent volumes and densities were evaluated at the tableting materials. During tablet compression, compressibility was evaluated using the energy profile of the compression process. The tested tablet parameters were tensile strength, friability, disintegration and drug dissolution. Formulations with MicroceLac® 100 showed better flow properties. The addition of a retarding component worsened the flow properties. The values...
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