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Phytoextraction of Selected Pharmaceuticals
Hatasová, Nicolette ; Smrček, Stanislav (advisor) ; Soudek, Petr (referee)
The aim of this bachelor thesis is a study of phytoextraction of trazodone which represents the active component of an antidepressant sold under the name Trittico. Trazodone is not completely metabolized in organisms and part of drug is excreted unchanged by urinary system to wastewater. Phytoextraction represents new and economical method used to remove residual concentrations of pollutants in aquatic ecosystems. These substances enter the environment even after previous cleaning in wastewater treatments plants. The removal of pharmaceutical residues is generally not sufficient which is related to development of more effective methods. Plant maize (Zeamays) was used for this experiment in which degradation effectivity was monitored for eight days. Concentrations of trazodone in various cultivations were determined by HPLC. Results showed that selected antidepressant was extracted during the experiment and phytoextractiontook place. Key words: phytoextraction, wastewater treatment plants, wastewater, pollution, antidepressants, trazodone
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Fluorinated micropollutants in the environment
Hatasová, Nicolette ; Cajthaml, Tomáš (advisor) ; Klusoň, Petr (referee)
Perfluorinated compounds (PFCs) are considered as persistent organic pollutants. Their extensive use in various products leads to increase of their occurence in surface and ground water, soil, air and, generally, in the global ecosystem. In this diploma thesis, method for detection and quantification of 19 perfluorinated compounds was developed. This method was used for analysis of real drinking water and sewage sludge samples from Czech Republic. It is based on pre-extraction step and consecutive liquid chromatography with mass spectrometry, using negative chemical ionization (LC-MS). We developed a method for analysis of water samples, using solid-phase extraction (SPE). Using this method, concentrations of PFCs in 8 samples of drinking water from Czech Republic were evaluated. Total concentration of analyzed PFCs was 4 - 23 ng/L. Processing of sewage sludge samples using accelerated solvent extraction (ASE) showed matrix effect, which influenced ionization and led to false positive/negative results. For supression of the matrix compounds, we used SPE Envi-Carb columns. Using this optimised method, 23 sewage sludge samples from different locations in Czech Republic were analyzed. The most represented PFC in the environment, perfluoroctane sulfonate (PFOS), was detected in concentrations 5 - 386...
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Phytoextraction of Selected Pharmaceuticals
Hatasová, Nicolette ; Smrček, Stanislav (advisor) ; Soudek, Petr (referee)
The aim of this bachelor thesis is a study of phytoextraction of trazodone which represents the active component of an antidepressant sold under the name Trittico. Trazodone is not completely metabolized in organisms and part of drug is excreted unchanged by urinary system to wastewater. Phytoextraction represents new and economical method used to remove residual concentrations of pollutants in aquatic ecosystems. These substances enter the environment even after previous cleaning in wastewater treatments plants. The removal of pharmaceutical residues is generally not sufficient which is related to development of more effective methods. Plant maize (Zeamays) was used for this experiment in which degradation effectivity was monitored for eight days. Concentrations of trazodone in various cultivations were determined by HPLC. Results showed that selected antidepressant was extracted during the experiment and phytoextractiontook place. Key words: phytoextraction, wastewater treatment plants, wastewater, pollution, antidepressants, trazodone
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