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Determination of pharmacological properties of potencial drugs for the treatment of Alzheimer's disease Schejbalová, Kateřina ; Herink, Josef (advisor) ; Vopršalová, Marie (referee) Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Mgr. Kateřina Schejbalová Supervisor: Doc. MUDr. Josef Herink, Dr.Sc. Consultant: Kpt. PharmDr. Vendula Hepnarová Title of thesis: Determination of pharmacokinetic properties of potential drugs for the treatment of Alzheimer's disease Alzheimer's disease (AD) is an illness caused by neurodegenerative changes in the brain tissue. It belongs to the diseases that lead to the origin of dementia. The occurrence of this illness has been rising over past years. Unfortunately, the causative treatment has not been found yet and the only available treatment is the symptomatic one. Therefore, it is necessary strive towards the discovery new and more efficient drugs. The aim of this thesis is to determinate the inhibiting concentrations and to measure the antioxidative activity of the new synthetic potential anti-Alzheimer drugs. Seven hybrids of 6 - chlorotacrine - tryptophan (6-Cl-THA-Trp), 7 - methoxytacrine - tryptophan (7-MEOTA-Trp) and tacrine - tryptophan (THA-Trp) were tested. The in vitro inhibiting potentials of the tested compounds against human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were evaluated. Spectrophotometer was used for the measurements by... Detailed record

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