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Synthesis of isotopically labeled ketamine
Stuchlíková, Lucie ; Lešetický, Ladislav (advisor) ; Smrček, Stanislav (referee)
In this work were synthesized ketamine isotopomers. Ketamine is used in human medicine and veterinary sectors. It has very broad spectrum of pharmacological effects: anesthetic, analgesic, hallucinogenic, bronchodilator, cardiovascular and antidepressive, which is currently in the research. At first was synthesized precursor of ketamine, N- desmethylketamine which was subsequently labeled the deuterium, tritium and carbon- 14. For the determination of purity and identity mass spectrometry and nuclear magnetic resonance spectroscopy were used. KEY WORDS synthesis of ketamine, ketamine, N-desmethylketamine, nor-ketamine, isotopically labeled ketamine, deuterium, tritium, carbon-14.
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