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Development of liquisolid systems for colon targeting
Ogadah, Chiazor Ugo ; Vraníková, Barbora (advisor) ; Zámostný, Petr (referee) ; Gajdziok, Jan (referee)
Univerzita Karlova, Farmaceutická Fakulta V Hradci Králové Školicí pracoviště: Katedra Farmaceutické Technologie Doktorský studijní program: Farmaceutická Technologie Kandidátka: Mgr. Chiazor Ugo Ogadah Školitelka: doc. PharmDr. Barbora Vraníková, Ph.D. Konzultantka: doc. Prof. PharmDr. Zdeňka Šklubalová, Ph.D. Název dizertační práce: Vývoj liquisolid systémů s cíleným přívodem léčiva do kolonu V lokální nebo systémové terapii chorob tlustého střeva mají systémy cílící do kolonu slibnou perspektivu. Úspěch však představuje výzvu díky fyziologickým bariérám trávicího traktu. Pokud zvýšení rozpustnosti léčiva předchází cílení, lze rozpouštění, jako krok limitující rychlost, obejít, urychlit vstřebání léčiva a zvýšit jeho perorální biodostupnost. Pro optimalizaci dávky a terapeutického efektu je kromě toho potřebné zadržet přípravek v místě cílení. Cílem této práce je proto vývoj systému pro doručení a cílení omezeně rozpustného léčiva cyklosporinu A (CyA) do kolonu. V první části experimentu byly využity preformulační studie k dosažení zvýšené rozpustnosti a zrychleného uvolnění CyA pomocí tzv. liquisolid sytému (LSS) nebo přípravou interaktivních směsí společným mletím (komletím). To zahrnovalo výběr vhodného nosiče a hodnocení jeho vlastností při mletí, stejně jako výběr netěkavého...
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Influence of lubricants on viscoelastic parameters of compaction process
Svačinová, Petra ; Rabišková, Miloslava (advisor) ; Kubová, Kateřina (referee) ; Zámostný, Petr (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical technology Candidate Mgr. Petra Svačinová Supervisor Prof. PharmDr. Miloslava Rabišková, CSc. Title of Doctoral Thesis Influence of lubricants on viscoelastic parameters of compaction process This thesis deals with an evaluation of lubricant's influence on viscoelastic parameters of compaction process. The force-displacement record and stress relaxation test were used for this evaluation. This study evaluates the viscoelastic parameters on three fillers intended for direct compression, i.e. microcrystalline cellulose Avicel PH-200, lactose Lactochem Fine Crystals and calcium hydrogen phosphate dihydrate Emcompress. Magnesium stearate and modified colloidal silica Syloid were used as lubricants at concentrations of 0.5 % and 1 %. Particle size and shape and specific surface area were determined for all used excipients. Flow properties were studied for individual fillers and also for their mixtures with lubricants. Subsequently, tablets were compressed from fillers and mixtures using force-displacement record and stress relaxation test, and viscoelastic parameters were evaluated. The applied compression forces for both methods were 5 kN, 10 kN and 15 kN. The hardness of tablets was measured. The results show...
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Study of flow and consolidation behaviour of binar mixtures of Cellets and filler for preparation of multilayer tablets
Jarolímová, Žofie ; Šklubalová, Zdeňka (advisor) ; Franc, Aleš (referee) ; Zámostný, Petr (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate Mgr. Žofie Jarolímová Supervisor doc. PharmDr. Zdeňka Šklubalová, Ph.D. Title of Doctoral Thesis Study of flow and consolidation behaviour of binary mixtures of Cellets and filler for preparation of multilayer tablets The manufacture and quality of solid dosage forms is influenced mainly by flow, consolidation and compaction properties of powder excipients. In this work, the behaviour of pellets made of microcrystalline cellulose (cellets), which might be used as a drug carrier in multilayer tablets, and their binary mixtures with microcrystalline cellulose was studied. More than 20 powder excipients commonly used in tablet production and their binary mixtures were involved in preliminary studies. Measuring of the angle of repose, Hausner ratio and the mass flow rate through a hopper orifice was influenced by the particle shape, size and the width of the particle size distribution. In order to identify easily the free flowing substances, the hopper orifice having 10 mm diameter was useful. Excellent flow properties were confirmed for cellets with conventional testing methods thanks to their spherical shape and narrow particle size distribution. The avalanche testing using a rotational drum...
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Study of flow and consolidation behaviour of binar mixtures of Cellets and filler for preparation of multilayer tablets
Jarolímová, Žofie ; Šklubalová, Zdeňka (advisor) ; Franc, Aleš (referee) ; Zámostný, Petr (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate Mgr. Žofie Jarolímová Supervisor doc. PharmDr. Zdeňka Šklubalová, Ph.D. Title of Doctoral Thesis Study of flow and consolidation behaviour of binary mixtures of Cellets and filler for preparation of multilayer tablets The manufacture and quality of solid dosage forms is influenced mainly by flow, consolidation and compaction properties of powder excipients. In this work, the behaviour of pellets made of microcrystalline cellulose (cellets), which might be used as a drug carrier in multilayer tablets, and their binary mixtures with microcrystalline cellulose was studied. More than 20 powder excipients commonly used in tablet production and their binary mixtures were involved in preliminary studies. Measuring of the angle of repose, Hausner ratio and the mass flow rate through a hopper orifice was influenced by the particle shape, size and the width of the particle size distribution. In order to identify easily the free flowing substances, the hopper orifice having 10 mm diameter was useful. Excellent flow properties were confirmed for cellets with conventional testing methods thanks to their spherical shape and narrow particle size distribution. The avalanche testing using a rotational drum...
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Study of static and dynamic flow properties of pharmaceutical excipients
Hurychová, Hana ; Šklubalová, Zdeňka (advisor) ; Vetchý, David (referee) ; Zámostný, Petr (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Candidate: Ing. Hana Hurychová Supervisor: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Title of Doctoral Thesis: Study of static and dynamic flow properties of pharmaceutical excipients Flow properties are among the most significant characteristics of pharmaceutical materials. Recent modern technologies allow preparation of particles with modified surface properties and flow behaviour for the conventional as well as new excipients. In this work, the static (compressibility index, Hausner ratio, angle of repose, shear testing) and dynamic (flow rate, avalanche testing) flow properties of a wide variety of excipients, their particle size fractions and selected model mixtures were evaluated. In particular, attention was paid to modelling of the flow rate by the equation prospectively suitable for use in the standardization of flow testing in pharmaceutical technology. The power equation in which the equation parameter is a direct prediction of the flow rate through an orifice having a unit diameter is recommended. The basic granulometric characteristics of particles were completed with the particle fractal dimension (pDF) and the bulk fractal dimension (bDF). Although a relatively strong correlation between the...
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Influence of lubricants on viscoelastic parameters of compaction process
Svačinová, Petra ; Rabišková, Miloslava (advisor) ; Kubová, Kateřina (referee) ; Zámostný, Petr (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical technology Candidate Mgr. Petra Svačinová Supervisor Prof. PharmDr. Miloslava Rabišková, CSc. Title of Doctoral Thesis Influence of lubricants on viscoelastic parameters of compaction process This thesis deals with an evaluation of lubricant's influence on viscoelastic parameters of compaction process. The force-displacement record and stress relaxation test were used for this evaluation. This study evaluates the viscoelastic parameters on three fillers intended for direct compression, i.e. microcrystalline cellulose Avicel PH-200, lactose Lactochem Fine Crystals and calcium hydrogen phosphate dihydrate Emcompress. Magnesium stearate and modified colloidal silica Syloid were used as lubricants at concentrations of 0.5 % and 1 %. Particle size and shape and specific surface area were determined for all used excipients. Flow properties were studied for individual fillers and also for their mixtures with lubricants. Subsequently, tablets were compressed from fillers and mixtures using force-displacement record and stress relaxation test, and viscoelastic parameters were evaluated. The applied compression forces for both methods were 5 kN, 10 kN and 15 kN. The hardness of tablets was measured. The results show...
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Influence of lubricants on viscoelastic parameters of compaction process
Svačinová, Petra ; Rabišková, Miloslava (advisor) ; Kubová, Kateřina (referee) ; Zámostný, Petr (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical technology Candidate Mgr. Petra Svačinová Supervisor Prof. PharmDr. Miloslava Rabišková, CSc. Title of Doctoral Thesis Influence of lubricants on viscoelastic parameters of compaction process This thesis deals with an evaluation of lubricant's influence on viscoelastic parameters of compaction process. The force-displacement record and stress relaxation test were used for this evaluation. This study evaluates the viscoelastic parameters on three fillers intended for direct compression, i.e. microcrystalline cellulose Avicel PH-200, lactose Lactochem Fine Crystals and calcium hydrogen phosphate dihydrate Emcompress. Magnesium stearate and modified colloidal silica Syloid were used as lubricants at concentrations of 0.5 % and 1 %. Particle size and shape and specific surface area were determined for all used excipients. Flow properties were studied for individual fillers and also for their mixtures with lubricants. Subsequently, tablets were compressed from fillers and mixtures using force-displacement record and stress relaxation test, and viscoelastic parameters were evaluated. The applied compression forces for both methods were 5 kN, 10 kN and 15 kN. The hardness of tablets was measured. The results show...
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Use tap Dance in the Movie and on the Stage
Waidingerová, Andrea ; ZÁMOSTNÝ, Petr (advisor) ; CAPKO, Štefan (referee)
Tap dance represents quite a new and popular dance style. It entertains both dancers and spectators. We can find tap dance in various movies, world tap records, in drummer, tap and pure dance shows that reached the deepest level of today?s spectator?s hearts and purses. This thesis deals with a named movies and tap records. Another focus is on musical film that have been forgotten, contemporary silent movie, history of tap dance and theatre performance, which transfer the rhythmical message to the spectator directly from the stage. Here you can learn about the tap dance used as a musical instrument, expression of diverse emotions and feelings like joy, frustration, pension, cynicism or arrogance, as a main means of theatre dramaturgy or as an amazing show, which the tap dance definitely is.
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American tap dance - My own experiences
Hlava, Nina ; Zámostný, Petr (advisor) ; Zárubová-Pfeffermannová, Noemi (referee)
The following Magister Diploma work is about the evolution and traditon of the American dance called "Tap" With the addition of the personal experiences of the author, this work is written like a report in the first person narrative. Because of the fact that this kind of dance was founded in the United States, the focal point is given to American dancers and choreographers. It also will inform the reader about the technique of American Tap Dance and the specific terminology, which is used throughout the entire document. The main goal of this diploma work is to provide a basis about "Tap". It also serves as a reference guide for students interested in the topic by providing contact addresses of several institutions in America but also in Czech Republic.
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