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Quantification of skin ceramides in patients after oncological treatment
 Voláková, Eliška ; Opálka, Lukáš (advisor) ; Roh, Jaroslav (referee)
Charles University, Faculty of pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Candidate: Eliška Voláková Supervisor: PharmDr. Lukáš Opálka, Ph.D. Title of diploma thesis: Quantification of skin ceramides in patients after oncological treatment Ceramides are one of the three basic lipid components present in the stratum corneum of human skin. Alterations in the ratio of individual ceramides are associated with disruption of skin barrier function. Such changes have been observed not only in skin diseases of the non-cancerous type, but also as a consequence of cancer. The main aim of the present study was to investigate the difference in the representation of skin ceramides in the stratum corneum of healthy patients and patients after cancer. Samples were collected from five groups of patients, four of which represented cancer patients with different types of treatment: tumor resection, chemotherapy, radiation or a combination of chemotherapy and radiation. The remaining fifth group consisted of control samples from volunteers without a diagnosis of cancer. Samples were obtained by tape-stripping from an identical site on patient forearm, followed by protein determination. Cancer patient samples were compared with control samples in terms of different water loss through the...
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