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National Repository of Grey Literature 12 records found  previous11 - 12  jump to record: Search took 0.00 seconds. 
The role of the IFT machinery in the construction of the eukaryotic flagellum/cilium
 Šlapal, Filip ; Varga, Vladimír (advisor) ; Libusová, Lenka (referee)
Intraflagelar transport (IFT) is a bidirectional continuous process providing growth, maintenance and remodeling of eukaryotic cilia and flagella. The cilia and flagella are microtubular-based organelles with several functions such as signalling and motility. Building blocks of the ciliary cytoskeleton are produced in the cell body and needs to be transported to the distal end, which is the sole place of their assembly. This transport is facilitated by the IFT complexes, which are carried from the cell body along the microtubules towards the distal end by kinesin motor protein. Subsequent recycling of the IFT units as well as turnover of ciliary building blocks is facilitated by dynein powered movement towards the cell body. The regulation of this process is still unknown. While composition of the IFT machinery has been characterized, the processes related to IFT switch from distal-end directed to the proximal-end directed, which happens at the ciliary tip, are largely unknown. Another outstanding question concerns how is the IFT regulated in order to achieve a defined length of the cilium. This thesis briefly examines the structure of cilium, composition of the IFT machinery and the processes occurring during the transport and discuss several possible models of IFT regulation.
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Monoxenous trypanosomatids of invertebrates
 Havlová, Jolana ; Votýpka, Jan (advisor) ; Varga, Vladimír (referee)
The class Kinetoplastea contains free-living and parasitic species. One of the most dominant group within the class is the order Trypanosomatida which includes obligate parasites (Trypanosoma, Leishmania) infecting a wide range of hosts. Some species are serious pathogens of humans and domestic animals and cause considerable losses. However, the majority of trypanosomatids belongs to monoxenous parasites of insect which are usually harmless to their hosts. Monoxenous trypanosomatids predominantly infect Hemiptera and Diptera. This diploma thesis is focused on the detection of monoxenous trypanosomatids in cockroaches captured in the Czech Republic and cockroaches from different breedings. Cockroaches are very suitable mechanical vectors of many different pathogens (including parasites) and are significant health threat for humans and animals. First trypanosomatids in cockroaches were documented at the beginning of the 20th century, but there is no study focused on this topic specifically. Another aim of this thesis is morphological and ultramicroscopic analysis and the study of the host specificity of the recently described species Herpetomonas tarakana, isolated from a cockroach. My findings were partly used in the already published study "Diversity of trypanosomatids in cockroaches and the...
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National Repository of Grey Literature : 12 records found   previous11 - 12  jump to record:
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