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Beta-lactam Antibiotics Level Monitoring in Febrile Neutropenia Patients and Patients with Sepsis
Zavřelová, Alžběta ; Žák, Pavel (advisor) ; Válková, Veronika (referee) ; Krejčí, Marta (referee)
Beta - lactam antibiotics level monitoring in febrile neutropenia patients and patients with sepsis. Monitoring of antibiotic blood concentration in hemato-oncological patients was primary objective of this work. Monitoring of antibiotics level were done mainly in antibiotics used for gram-negative infections treatment (piperacilline, meropenem, ceftazidime) or for the treatment of febrile immunocompromised patient, usually neutropenic. For individual pharmacokinetics evaluation blood concentration were taken during the administration of prolonged antibiotics infusion. It was further used to create population model. Monte Carlo simulation was then used for creation of final model and for demonstration of pharmacokinetics/pharmacodynamics goals. Pharmacokinetics/pharmacodynamics goals were primary aim of whole study for different antibiotics during the use in stable hemato-oncological patients but also critical patients. Clinical data were used for further study, where we proved high clinical efficacy of high dose ceftazidime in the treatment of extended drug resistant Pseudomonas aeruginosa infection in hemato-oncological patients.
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Social structure and agonistic behaviour in western lowland gorilla (Gorilla gorilla gorilla) group in Prague ZOO
Válková, Veronika ; Vančata, Václav (advisor) ; Marván, Richard (referee)
In our research we analysed social structure, interindividual relationships and social and agonistic behaviour in captive gorillas. Data were obtained from a group of six western lowland gorilla (Gorilla gorilla gorilla) individuals during a continuous one year period observation in Prague ZOO. We assumed, that silverback is dominant to other individuals in the group and that there is no long-term social hierarchy between adult females. Likewise, that afiliative and agonistic behaviour is distributed unequal within the group and that the high-level visit rate increases the agonistic behaviour of gorillas. Sampling methods were: ad libitum sampling, focal animal sampling and all occurence sampling. For statistical data analysis we used specialized software (Noldus - MatMan LO). We confirmed, that the silverback has dominant position in the group and relationships between females are egalitarian. Afiliative contacts were observed only between females and young individuals or in young induviduals with each other. There is an unequal distribution of agonistic behaviour in the group and silverback's agonistic behaviour appears to response to agonistic encounters in females. The influence of highlevel visit rate to agonistic behaviour occurence were not confirmed. Our conclusion is, that gorillas in Prague ZOO,...
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J. D. Salinger's "A Perfect Day for Bananafish" Translation. Linguo-stylistic Analysis
Válková, Veronika ; Hirschová, Milada (advisor) ; Holanová, Radka (referee)
This thesis aims to analyse several translations of J.D. Salinger's short story A Perfect Day for Bananafish: namely two translations and two edited versions of the latter one. The contrastive view is used to discern the main differences in meaning of the original and the translated texts. There are several points of view adopted to recognise the differences. On the syntactic level, the contrast between the texts was found to be present in the treatment of the author's style, predominantly in the narrative perspective. Not employing nominal structures a great deal, the author's style was not lost in the translation process. Comparing the translated texts, a tendency to adhere to the syntactic surface structure of the original text was found in the less recent versions. Another level of analysis explored the temporal relations of the texts, with the original text relying mostly on structures expressing sequences of events and also simultaneity of events, but not the perfective aspect to a great degree. These time relations are also found to be communicated in the translated texts successfully. It is not only the narrator that is discussed in this thesis, as a great portion of the short story consist of dialogues. The analysis aimed, using certain excerpts of the story, to find to what degree...
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Social structure and agonistic behaviour in western lowland gorilla (Gorilla gorilla gorilla) group in Prague ZOO
Válková, Veronika ; Marván, Richard (referee) ; Vančata, Václav (advisor)
In our research we analysed social structure, interindividual relationships and social and agonistic behaviour in captive gorillas. Data were obtained from a group of six western lowland gorilla (Gorilla gorilla gorilla) individuals during a continuous one year period observation in Prague ZOO. We assumed, that silverback is dominant to other individuals in the group and that there is no long-term social hierarchy between adult females. Likewise, that afiliative and agonistic behaviour is distributed unequal within the group and that the high-level visit rate increases the agonistic behaviour of gorillas. Sampling methods were: ad libitum sampling, focal animal sampling and all occurence sampling. For statistical data analysis we used specialized software (Noldus - MatMan LO). We confirmed, that the silverback has dominant position in the group and relationships between females are egalitarian. Afiliative contacts were observed only between females and young individuals or in young induviduals with each other. There is an unequal distribution of agonistic behaviour in the group and silverback's agonistic behaviour appears to response to agonistic encounters in females. The influence of highlevel visit rate to agonistic behaviour occurence were not confirmed. Our conclusion is, that gorillas in Prague ZOO,...
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