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Retinal nerve fiber layer measurement in patients with Alzheimer's disease
Kasl, Zdeněk ; Jirásková, Naďa (advisor) ; Pašta, Jiří (referee) ; Skorkovská, Šárka (referee)
Retinal nerve fiber layer measurement in patients with Alzheimer's disease The current ophthalmologist's possibilities in diagnostics of Alzheimer's disease Alzheimer disease (AD) is the most common cause of dementia syndrome and mild cognitive impairment. To enroll the disease most securely there are used so called biomarkers using evidence of changed brain metabolism by pozitron emission tomography (PET) and in cerebrospinal fluid or the brain's structure magnetic resonance imaging (MRI). These methods are expensive, organisationally and temporally challenging and burdening for the patients. According to that reasons we are still seeking for alternative attitudes suitable for early diagnosis. The evaluation of thickness of retinal nerve fiber layer (RNFL) which is well accessible to examination through optical aparatus of the eye could be one of the options. The aim of our work was to present current knowledges about Alzheimer's disease targeting relations of Alzheimer's disease and an ophthalmological finding. In the next part of this paper we introduce the retinal nerve fiber layer measurement by optical coherence tomography (OCT) as a potential diagnostics method by screening of patients with Alzheimer's disease and to present our results measured in our cohort of patients. The studied cohort...
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Improvement in the Quality of Life in Patients with Stable Maculopathy by Scharioth Macula Lens Implantation and Visual Plasticity Modulation by Transcranial Electrical Stimulation
Středová, Markéta ; Jirásková, Naďa (advisor) ; Pašta, Jiří (referee) ; Skorkovská, Šárka (referee)
Improvement in the quality of life in patients with stable maculopathy by Scharioth macula lens implantation and visual plasticity modulation by transcranial electrical stimulation Aim: To evaluate the change in the quality of life in patients with stable maculopathy after Scharioth macula lens (SML) implantation followed by transcranial electrical stimulation (tES) and visual rehabilitation. Methods: Our prospective study included 14 patients with dry age-related macular degeneration (AMD) who underwent SML implantation from May 2018 to September 2019 at the Ophthalmology Clinic of the University Hospital in Hradec Kralove. The follow-up period was 6 months. The evaluated parameters were distant best corrected visual acuity (BCVA), near uncorrected visual acuity (UNCVA), intraocular pressure (IOP), central retinal thickness (CRT) and visual plasticity in the form of visual evoked potentials (VEP). The occurence of any complications and subjective satisfaction were also assessed. Results: The mean preoperative distant BCVA was 0.23 ± 0.09 and 0.17 ± 0.06 at 6 months. The mean preoperative near UNCVA was Jäger (J) 14.9 ± 2.1 and J 4.2 ± 3.1 at 6 months. Preoperative mean near visual acuity (VA) with addition of +6 diopters was J 5.0 ± 2.3. There was no statistically significant difference in the near...
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Correction of Myopia and Myopic Astigmatism by Implantation of Phakic Posterior Chamber Implantable Collamer Lens
Řeháková, Tereza ; Jirásková, Naďa (advisor) ; Pašta, Jiří (referee) ; Skorkovská, Šárka (referee)
Aim: We analysed two years results in patients with correction of moderate-to-high myopia or myopic astigmatism by implantation of posterior chamber phakic intraocular Impantable Collamer Lens (ICL). Methods: To the retrospective study were included 63 eyes of 32 patients (3 men, 29 women), who underwent implantation of ICL between 2007 - 2016 in the outpatient Department of Ophthalmology clinic, University Hospital in Hradec Králové, to correction moderate-to-high myopia or myopic astigmatism. We assess uncorrected visual acuity (UCVA) and best spectacle-corrected visual acuity (BSCVA), subjective refraction, intraocular pressure (IOP), endothelial cell density (ECD) and the incidence of complications in the two years follow-up period. Results: At the time of implantation the mean patient's age was 28,14 ± 5,35 years (range 21 to 36 years). The mean preoperative subjective refraction improved from -7,8 ± 2,7 D sf (range - 14 to -3,25 D sf) and -0,65 ± 0,8 D cyl (range -3,25 to 0 D cyl) to -0,01 ± 0,1 D sf (range -0,75 to 0 D sf) and -0,05 ± 0,16 D cyl (range -0,55 až 0 D cyl). The mean ECD value was 3270,5 ± 454,7 cells/mm2 (range 2155 to 4201 cells/mm2 ) compared to 2803,4 ± 441,8 cells/mm2 (range 2079 to 4184 cells/mm2 ) at the end of our follow-up period. The percentage loss of ECD two years...
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Mapping of Changes in Oxygen Saturation in Retinal Vessels Related to the Extent of Periperal Nonperfusion in Patients with Retinal Vein Occlusion
Šínová, Irena ; Jirásková, Naďa (advisor) ; Pašta, Jiří (referee) ; Skorkovská, Šárka (referee)
Mapping of changes in oxygen saturation in retinal vessels related to the extent of peripheral nonperfusion in patients with retinal vein occlusion Purpose: The aim of this study was to evaluate the relationship between the ischemic index and the oxygen saturation in retinal vessels in patients with retinal vein occlusion. Methods: We performed a prospective, cross-sectional study. The cohort consisted of 43 eyes of 43patients with retinal vein occlusions (RVO), 23 of whom had central retinal vein occlusions (CRVO) and 20 who had branch retinal vein occlusions (BRVO). We evaluated the retinal vessel saturation using an automatic retinal oximetry device (Oxymap Inc., Reykjavik, Iceland). The retinal ischemic index (ISI) was determined using ultra-wide-field fluorescein angiography (Heidelberg Engineering GmbH, Heidelberg, Germany). Results: Mean arterial saturation (± SD) was 100 ± 11 %, mean vein saturation was 52 ±13 % and mean A-V difference was 48 ± 16 % in eyes with BRVO. The average ISI inthe same group was 0.48 (range 0-1). There was no statistically significant correlation between the retinal ischemic index and retinal saturation in the BRVO group. The affected eye in the CRVO group had a mean arterial saturation of 101 ± 6 %, vein saturation of 44 ± 11 % and A- V difference of 58 ± 10 %. The...
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Retinal nerve fiber layer measurement in patients with Alzheimer's disease
Kasl, Zdeněk ; Jirásková, Naďa (advisor) ; Pašta, Jiří (referee) ; Skorkovská, Šárka (referee)
Retinal nerve fiber layer measurement in patients with Alzheimer's disease The current ophthalmologist's possibilities in diagnostics of Alzheimer's disease Alzheimer disease (AD) is the most common cause of dementia syndrome and mild cognitive impairment. To enroll the disease most securely there are used so called biomarkers using evidence of changed brain metabolism by pozitron emission tomography (PET) and in cerebrospinal fluid or the brain's structure magnetic resonance imaging (MRI). These methods are expensive, organisationally and temporally challenging and burdening for the patients. According to that reasons we are still seeking for alternative attitudes suitable for early diagnosis. The evaluation of thickness of retinal nerve fiber layer (RNFL) which is well accessible to examination through optical aparatus of the eye could be one of the options. The aim of our work was to present current knowledges about Alzheimer's disease targeting relations of Alzheimer's disease and an ophthalmological finding. In the next part of this paper we introduce the retinal nerve fiber layer measurement by optical coherence tomography (OCT) as a potential diagnostics method by screening of patients with Alzheimer's disease and to present our results measured in our cohort of patients. The studied cohort...
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