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Changes in the iron metabolism and its regulation in patients with end-stage renal disease treated by hemodialysis and kidney transplantion
Turková Sedláčková, Terezie ; Racek, Jaroslav (advisor) ; Zima, Tomáš (referee) ; Teplan, Vladimír (referee)
Iron is a very important biogenous trace element, which is involved in many of cell processes in organism. For its character iron can be also involved in Fenton reaction, where a toxic hydroxyl radical is produced. The iron metabolism is very carefully regulated in order to avoid formation of hydroxyl radical. Iron Responsive Proteins-Iron Responsive Elements (IRPs-IREs) system is involved in the regulation of iron metabolism on cell level, small peptide hormon hepcidin is involved in the regulation on systemic level. Hepcidin was discovered in 2000 as a peptide with antimicrobial properties. It is a key regulator of iron metabolism, as was discovered later. The target of hepcidin is ferroportin-the only known iron cell exporter. The expression of hepcidin is downregulated by hypoxia and anemia and upregulated by iron overload and inflammation. Hemodialyzed patients suffer from anemia very often. This anemia is caused by many factors, e.g. inadequate production of erythropoietin, chronic inflammation, chronic oxidative stress, blood loss during hemodialysis process or lower lifetime of red blood cells. We realized three studies on the patients with end-stage renal disease in our laboratories. Our aim was to find a relationship of hepcidin and other parameters of iron metabolism, inflammation and...
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Biblical Intertextuality in Torgny Lindgren's Novels
Sedláčková, Terezie ; Stahr, Radka (advisor) ; Humpál, Martin (referee)
This thesis analyses biblical intertextuality in selected novels of the Swedish writer Torgny Lindgren. The goal of the thesis is to determine the ways of use and the function of biblical intertextuality in Lindgren's work. The paper consists of two parts. The first, theoretical part outlines the theory of intertextuality and the life and work of Torgny Lindgren. The second, practical part contains detailed analyses of the novels Ormens väg på hälleberget (1982, The Way of a Serpent), Bat Seba (1984, Bathsheba) and Norrlands akvavit. The analysis shows the plurality of ways Lingren uses to involve biblical intertextuality in individual novels. Biblical intertextuality helps to define main topics of the novels which leads the reader to think about the general questions of human life. key words: Swedish literature - Torgny Lindgren - Bible - Intertextuality - Biblical intertextuality - Biblical stories - Biblical characters
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Changes in the iron metabolism and its regulation in patients with end-stage renal disease treated by hemodialysis and kidney transplantion
Turková Sedláčková, Terezie ; Racek, Jaroslav (advisor) ; Zima, Tomáš (referee) ; Teplan, Vladimír (referee)
Iron is a very important biogenous trace element, which is involved in many of cell processes in organism. For its character iron can be also involved in Fenton reaction, where a toxic hydroxyl radical is produced. The iron metabolism is very carefully regulated in order to avoid formation of hydroxyl radical. Iron Responsive Proteins-Iron Responsive Elements (IRPs-IREs) system is involved in the regulation of iron metabolism on cell level, small peptide hormon hepcidin is involved in the regulation on systemic level. Hepcidin was discovered in 2000 as a peptide with antimicrobial properties. It is a key regulator of iron metabolism, as was discovered later. The target of hepcidin is ferroportin-the only known iron cell exporter. The expression of hepcidin is downregulated by hypoxia and anemia and upregulated by iron overload and inflammation. Hemodialyzed patients suffer from anemia very often. This anemia is caused by many factors, e.g. inadequate production of erythropoietin, chronic inflammation, chronic oxidative stress, blood loss during hemodialysis process or lower lifetime of red blood cells. We realized three studies on the patients with end-stage renal disease in our laboratories. Our aim was to find a relationship of hepcidin and other parameters of iron metabolism, inflammation and...
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