|
|
Polymeric nanoparticles: platform for poorly water soluble drugs delivery
Roztočilová, Adéla ; Holas, Ondřej (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Mentor: PharmDr. Ondřej Holas, Ph.D. Student: Adéla Roztočilová Title of thesis: Polymeric nanoparticles as a platform for delivery of poorly water-soluble drugs Polymer nanoparticles can be used as drug carriers due to their beneficial properties. One of the advantages of polymeric nanoparticles is, for example, to increase the solubility of drugs in water. They have great potential in the therapy of inflammatory diseases such as Crohn's disease or in shifting cancer pharmacotherapy. The main objective of this thesis was to prepare polymeric nanoparticles with encapsulated curcumin as model active ingredient. Four types of poly(lactic-co-glycolic acid) (PLGA) copolymer were used to prepare the nanoparticles. Nanoprecipitation and emulsion evaporation methods were employed. The parameters evaluated were encapsulation efficiency, drug loading, particle size and polydispersity. Both the water phase, where two different surfactants were employed, and the organic phase were varied during the experiment. The experimental part also used a dissociation method where two types of PLGA copolymer were compared and during the dissociation, samples were taken at predetermined times to determine the total...
|
guest ::
RSS feed.