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Study of interaction of negatively charged vesicular systems with polycations
Repová, Romana ; Klučáková, Martina (referee) ; Mravec, Filip (advisor)
This diploma thesis deals with the preparation and characterization of negatively charged catanionic vesicular systems and their combination with selected polycations. The catanionic vesicular system was prepared by mixing of two oppositely charged surfactants SDS and CTAB. The negative charge as well as the stability of the vesicular system was provided by the incorporation of phosphatidic acid. Polycations, DEAE and TMC, have been selected for use in a pharmaceutical applications. Characterization of the prepared systems was performed by measuring DLS and ELS. The results indicate that we were able to prepare stable negatively charged vesicles that were eligible to non-covalently interact with selected polycations.
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Catanionic vesicular systems
Repová, Romana ; Krouská, Jitka (referee) ; Mravec, Filip (advisor)
This bachelor thesis deals with catanionic vesicles. The aim of the study was to prepare and characterize these systems. The catanionic vesicles are composed of cationic (CTAB, CTAC, TTAB, DTAB) and anionic surfactants (SDS). The physical stability of the vesicles was enhanced with the addition of cationic surfactant DODAC.The catanionic vesicles were characterized by the measurement of the dynamic light scattering, zeta potencial and fluorescence correlation spectroscopy. The size and stability of the system were determined using dynamic light scattering. Difussion coefficient of the system was analyzed using fluorescence correlation spectroscopy.
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Study of interaction of negatively charged vesicular systems with polycations
Repová, Romana ; Klučáková, Martina (referee) ; Mravec, Filip (advisor)
This diploma thesis deals with the preparation and characterization of negatively charged catanionic vesicular systems and their combination with selected polycations. The catanionic vesicular system was prepared by mixing of two oppositely charged surfactants SDS and CTAB. The negative charge as well as the stability of the vesicular system was provided by the incorporation of phosphatidic acid. Polycations, DEAE and TMC, have been selected for use in a pharmaceutical applications. Characterization of the prepared systems was performed by measuring DLS and ELS. The results indicate that we were able to prepare stable negatively charged vesicles that were eligible to non-covalently interact with selected polycations.
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Catanionic vesicular systems
Repová, Romana ; Krouská, Jitka (referee) ; Mravec, Filip (advisor)
This bachelor thesis deals with catanionic vesicles. The aim of the study was to prepare and characterize these systems. The catanionic vesicles are composed of cationic (CTAB, CTAC, TTAB, DTAB) and anionic surfactants (SDS). The physical stability of the vesicles was enhanced with the addition of cationic surfactant DODAC.The catanionic vesicles were characterized by the measurement of the dynamic light scattering, zeta potencial and fluorescence correlation spectroscopy. The size and stability of the system were determined using dynamic light scattering. Difussion coefficient of the system was analyzed using fluorescence correlation spectroscopy.
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