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Comparison of Photophysical Properties of Different Types of Azaphthalocyanines
Reimerová, Petra ; Nováková, Veronika (advisor) ; Kubíček, Vladimír (referee)
Charles Univerzity in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Biophysics and Physical Chemistry Candidate: Petra Reimerová Supervisor: PharmDr. Veronika Nováková, Ph.D. Title of Thesis: Comparison of Photophysical Properties of Different Types of Azaphthalocyanines Phthalocyanines and their aza-analogues azaphthalocyanines are organic dyes with planar macrocyclic structure and metal cation coordinated in the center. They can be used in many applications - for example as sensors, dyes or sensitizers in photodynamic therapy. The aim of this study was to compare photophysical properties (absorption, fluorescence, singlet oxygen production), solubility, aggregation and acid-base properties of several molecules 1-7 that differ in the type of macrocyclic core (see Figure below). The strength of absorption expressed as an extinction coefficient increased with the bathochromic shift of the Q-band. The position of the Q band depended on the number of conjugated double bonds and on the position of the peripheral substituents. Isosteric exchange of benzene rings to pyrazine rings shifted Q-band to shorter wavelength. Quantum yields of singlet oxygen (Φ∆) and quantum yields of fluorescence (ΦF) were determined in pyridine and THF by comparative method with ZnPc as a reference....
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Analysis of drugs and potential drugs in biological material using liquid chromatography
Reimerová, Petra ; Štěrbová, Petra (advisor) ; Kujovská Krčmová, Lenka (referee) ; Žďárová Karasová, Jana (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Mgr. Petra Reimerová Supervisor: doc. PharmDr. Petra Štěrbová, Ph.D. Title: Analysis of drugs and potential drugs in biological material using liquid chromatography Bioanalytical methods play important role during development of new drugs. This is because determining the concentration of the drug of interest in biological matrices can help to reveal its mechanism of action, determine the values of basic pharmacokinetic parameters or study the fate of a potential drug during in vitro experiments. Considering the complexity of biological samples and low concentrations of studied compounds, the sample preparation prior to analysis is really important. Miniaturized techniques derived from standard extraction methods have significant presence in modern bioanalysis, mainly because they decrease both required sample volume and consumption of laboratory material to a minimum, and they enable automatization. One of the main areas of drug discovery is currently the treatment of cancer. Unfortunately, development of highly efficacious drugs and prolongation of patient survival have resulted in the risk of developing late complications associated with anticancer treatment...
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Analysis of drugs and potential drugs in biological material using liquid chromatography
Reimerová, Petra ; Štěrbová, Petra (advisor) ; Kujovská Krčmová, Lenka (referee) ; Žďárová Karasová, Jana (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Mgr. Petra Reimerová Supervisor: doc. PharmDr. Petra Štěrbová, Ph.D. Title: Analysis of drugs and potential drugs in biological material using liquid chromatography Bioanalytical methods play important role during development of new drugs. This is because determining the concentration of the drug of interest in biological matrices can help to reveal its mechanism of action, determine the values of basic pharmacokinetic parameters or study the fate of a potential drug during in vitro experiments. Considering the complexity of biological samples and low concentrations of studied compounds, the sample preparation prior to analysis is really important. Miniaturized techniques derived from standard extraction methods have significant presence in modern bioanalysis, mainly because they decrease both required sample volume and consumption of laboratory material to a minimum, and they enable automatization. One of the main areas of drug discovery is currently the treatment of cancer. Unfortunately, development of highly efficacious drugs and prolongation of patient survival have resulted in the risk of developing late complications associated with anticancer treatment...
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Analysis of drugs and potential drugs in biological material using liquid chromatography
Reimerová, Petra ; Štěrbová, Petra (advisor) ; Kujovská Krčmová, Lenka (referee) ; Žďárová Karasová, Jana (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Mgr. Petra Reimerová Supervisor: doc. PharmDr. Petra Štěrbová, Ph.D. Title: Analysis of drugs and potential drugs in biological material using liquid chromatography Bioanalytical methods play important role during development of new drugs. This is because determining the concentration of the drug of interest in biological matrices can help to reveal its mechanism of action, determine the values of basic pharmacokinetic parameters or study the fate of a potential drug during in vitro experiments. Considering the complexity of biological samples and low concentrations of studied compounds, the sample preparation prior to analysis is really important. Miniaturized techniques derived from standard extraction methods have significant presence in modern bioanalysis, mainly because they decrease both required sample volume and consumption of laboratory material to a minimum, and they enable automatization. One of the main areas of drug discovery is currently the treatment of cancer. Unfortunately, development of highly efficacious drugs and prolongation of patient survival have resulted in the risk of developing late complications associated with anticancer treatment...
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Comparison of Photophysical Properties of Different Types of Azaphthalocyanines
Reimerová, Petra ; Nováková, Veronika (advisor) ; Kubíček, Vladimír (referee)
Charles Univerzity in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Biophysics and Physical Chemistry Candidate: Petra Reimerová Supervisor: PharmDr. Veronika Nováková, Ph.D. Title of Thesis: Comparison of Photophysical Properties of Different Types of Azaphthalocyanines Phthalocyanines and their aza-analogues azaphthalocyanines are organic dyes with planar macrocyclic structure and metal cation coordinated in the center. They can be used in many applications - for example as sensors, dyes or sensitizers in photodynamic therapy. The aim of this study was to compare photophysical properties (absorption, fluorescence, singlet oxygen production), solubility, aggregation and acid-base properties of several molecules 1-7 that differ in the type of macrocyclic core (see Figure below). The strength of absorption expressed as an extinction coefficient increased with the bathochromic shift of the Q-band. The position of the Q band depended on the number of conjugated double bonds and on the position of the peripheral substituents. Isosteric exchange of benzene rings to pyrazine rings shifted Q-band to shorter wavelength. Quantum yields of singlet oxygen (Φ∆) and quantum yields of fluorescence (ΦF) were determined in pyridine and THF by comparative method with ZnPc as a reference....
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