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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Influence of germ-free conditions on the development of sensitization and tolerance to the main compound of brich pollen Bet v 1 in mice
 Kozáková, Hana ; Repa, A. ; Štěpánková, Renata ; Hrnčíř, Tomáš ; Hudcovic, Tomáš ; Tlaskalová, Helena ; Pollak, A. ; Wiedermann, U.
Birch pollen is one of the most frequent airborne allergen of Central and North Europe. The effect of intestinal microflora on sensitization and mucosal tolerance to main component of birch pollen Bet v 1 did not be study yet. Germ-free and conventional mice were administrated intragastrically or intranasally with Bet v 1 following by subcutaneous injections of Bet v 1. Tolerance was established independently on microflora present resulting decreased level of IgE and changed cytokine production
Detailed record
Vnímavost k navození nazální a orální tolerance je nezávislá na přítomnosti mikroflóry
 Repa, A. ; Kozáková, Hana ; Hudcovic, Tomáš ; Štěpánková, Renata ; Hrnčíř, Tomáš ; Tlaskalová, Helena ; Pollak, A. ; Wiedermann, U.
The development of mucosal tolerance to major allergic component of birch pollen in relationship with presence of intestinal microflora was the aim of presented study. Germ-free (GF) or conventionally reared (CV) BALB/c mice were intragastrically or intranasally pre-treated with Bet v 1 prior to sensitization performed by subcutaneous injections of Bet v 1. Oral as well as intranasal tolerance induction led to a significant reduction of allergen-specific antibody levels and IgE basophil degranulation, as well as cytokine production in vitro in both GF and CV mice. The importance of the microflora for mucosal tolerance induction in GF mice remains therefore a matter of debate
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