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Tower House - A Dominant in Prague 13 - Nové Butovice
Olekšák, Adam ; Stříteský, Pavel (referee) ; Palacký, Jiří (advisor)
The city district Praha 13 – Nové Butovice has changed over the last 40 years. From the land of villages and fields have become the housing estates and bussiness centers. That is why the territory is still looking own identity. One of the tools to achieve it, is building a monunent. The project focuses on urban integration and architectural design of the new dominant in this district. The proposal is based on theoretical analyzes of the area and experimental process for determining the location and form of the building with its surroundings. It also solves operational, disposition and architectural expressions of the exterior and interior of the building.
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The role of cytoskeleton in movement and navigation of neuronal growth cones
Olekšák, Adam ; Libusová, Lenka (advisor) ; Weissová, Romana (referee)
Growth cone is a dynamic structure localized at the tips of growing neurites. It detects guidance cues in the extracellular environment and enables growing neurite to properly respond to them. Cytoskeleton plays a key role in navigation of growing neurite. Microtubules and microfilaments enable the motion of the growth cone by generating force acting on the cytoplasmic membrane as well as on the substrate on which the neuron grows. Microfilaments are located mainly in the periphery of the growth cone. They are more dynamic than microtubules, and their polymerization and depolymerization enable formation of dynamic processes on the growth cone. These are used by neurons to gain information about their surroundings and for formation of adhesions on permissive substrates. Adhesions facilitate the growth of neurites. Direction, timing and speed of formation of the dynamic processes are regulated by a number of actin-associated proteins. These proteins are common targets of signalling pathways that are induced by activation of growth cones' cytoplasmic membrane-bound receptors by guidance cues. Along the microfilament bundles, microtubules enter the periphery of the growth cone aided by crosslinking and motor proteins. Microtubules are necessary for reducing the growth cone dynamics, the first step in...
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Tower House - A Dominant in Prague 13 - Nové Butovice
Olekšák, Adam ; Stříteský, Pavel (referee) ; Palacký, Jiří (advisor)
The city district Praha 13 – Nové Butovice has changed over the last 40 years. From the land of villages and fields have become the housing estates and bussiness centers. That is why the territory is still looking own identity. One of the tools to achieve it, is building a monunent. The project focuses on urban integration and architectural design of the new dominant in this district. The proposal is based on theoretical analyzes of the area and experimental process for determining the location and form of the building with its surroundings. It also solves operational, disposition and architectural expressions of the exterior and interior of the building.
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