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Complexes of metals as potential anion receptors
Marečková, Vendula ; Vojtíšek, Pavel (advisor) ; Mosinger, Jiří (referee)
An important class of anion receptors are based on bimetallic complexes with phenols bearing an pendant arms in 2,6-positions. A ligand of this type, 2,6-bis[(N- methylpiperazine-1-yl)methyl]-4-formyl phenol (L1), was prepared using the Mannich reaction. An attempt to prepare a similar compound L2 yield only an oily product. The molecular structure of compound L1 was determinated by X-ray diffraction. Comparison of the L1 structure with similar ones from CCDC showed important influence of the intramolecular H-bond on pendant arms orientations in this type of compounds. Further synthetic exploitation of the aldehyde group (in the position 4) was tested by reaction with 4-nitroaniline. The Shiff base (L3) was obtained but only as an oily substance. Reactions of L1 with Cu(ii) and Zn(ii) perchlorate or acetate produce complexes; the compound [Cu2L1(OH)(OAc)(H2O)]ClO4 (K1) was obtained in a crystallic form. The interactions of anion-bimetallic complex receptor were discused from stereochemical point of view using the structural data from CCDC in the last part of this work.
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The study of sulphonated polystyrene nanofabrics with encapsulated sensitizer
Hrdinková, Veronika ; Mosinger, Jiří (advisor) ; Vojtíšek, Pavel (referee)
The diploma thesis is dedicated to the exploitation of sulphonated polystyrene nanofibres as ion exchange nanomaterial. Ion exchange capacity of these nanomaterials has been determined by titration method and AAS. The effect of sulphonation on photophysical, photooxidative and photocytotoxic properties of sensitizer 5,10,15,20-meso- tetraphenylporphyrin (TPP) encapsulated in polystyrene nanofibres has been studied as well. Properties of TPP have been examined with time-resolved spectroscopy, photooxidation of uric acid as substrate and bactericidal tests on Escherichia coli DH5α with pGEM11Z plasmid. It has been discovered that following the sulphonation of the nanofabrics, the encapsulated sensitizer is partly present even in aggregation form. The polystyrene nanofabrics with encapsulated sensitizer keep its bactericidal efficiency also after sulphonation.
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Photooxidative and photodisinfective polymeric nanofabrics: The effect of oxygen permeability
Jesenská, Soňa ; Lang, Kamil (referee) ; Mosinger, Jiří (advisor)
The diploma thesis compares the photophysical, photooxidative and photocytotoxic properties of four polymer nanofabrics with encapsulated 5,10,15,20 - meso - tetraphenylporphyrin (TPP). The main focus of the work lies especially in the study of the effect of polymer oxygen permeability on the ability of nanofabrics to produce singlet oxygen and the utilization of nanofabrics for measurement of the polymer oxygen permeability and polymer oxygen diffusion coefficients. A possible application of nanofabrics in the framework of oxygen detection, photooxidation of substrates and photodesinfection has been studied as well.
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Sensitizers, Acceptors and Secondary Sources of Singlet Oxygen and Their Supramolecular Complexes with Cyclodextrins
Slavětínská, Lenka ; Mosinger, Jiří (advisor) ; Němcová, Irena (referee) ; Sýkora, Jan (referee)
l. Introduction 1.1. Singlet oxygen Singlet molecular oxygen 'o, 1'Á,) has been intensively investigated by the chemists and biologists over the few decades, primarily due to its high reactivity and cytotoxity. singlet oxygen is common term for oxygen molecules in two lowest-lying excited energy states lo2 1'Á.1 and 'oz('E.) differing in occupation of HoMo orbitals, energy and lifetime. First singlet excited state 'o, (t^r) is generated, if two electrons with antiparallel spin occupy one antibonding n* orbital. The configuration of the molecular orbitals ofthe singlet excited state r02(rts) is identical to that ofthe ground state' except that the last two electrons have antiparallel spinsr'2. Singlet oxygen is short-lived' highly oxidative cýotoxic species. Its |ifetime significantly depends on type of solvent2'r. Singlet oxygen can be generated vla photosensitized reaction. The mechanism includes the formation of the sensitizer triplet state and transfer of energy to triplet oxygen leading to lo,1'Á,) formation o.''u 1see Fig. l). Singlet ox;-'een can be a|so produced by the number of chemical reactions. e.g. using H2O2/CIO' ,.r, Hrorl MoOq2- e'r. and H2o2/cao2rr systems based on disproporcionation of H2o2that leads to H2o andrO2.
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