Home > Search Results: Michková, Petra
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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Changes in microbial colonization of gastrointestinal tract in patients after allogeneic hematopoietic stem cell transplantation
 Michková, Petra ; Mrázek, Jakub (advisor) ; Kodešová, Tereza (referee)
Introduction: Physiological microflora is characterised by wide diversity. The microbial community is mostly composed of bacteria, but also includes fungi, archaea and viruses. Anaerobic commensal bacteria (Firmicutes and Bacteroidetes) dominate 90% of the colon. The composition and products of the gut microbiota have a significant effect on an individual's immune system, and their interactions may ultimately promote immune tolerance or inflammatory immune response. Blood cell transplantation (HSCT) and its associated standard procedures of conditioning, antibiotic exposure and dietary prophylaxis represent modification and disruption of the gut microbiota leading to the development of some serious post-transplant complications affecting the OS (overall survival) and TRM (treatment related mortality) of patients. Objectives: The aim of this work was to investigate the representation of individual bacterial strains in patients undergoing allogeneic HSCT, as well as the effect of transplantation on the composition and diversity of their gut microbiota. Methods: Stool samples were obtained from 52 patients who underwent an allogeneic hematopoietic cell transplant at the Institute of Hematology and Blood Transfusion in Prague. A cut-off date for the first sample was set for the start of...
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Nutritional problems in patients with chronic graft-versus-host disease after allogeneic transplantation of hematopoietic cells
 Michková, Petra ; Šťastná-Marková, Markéta (advisor) ; Novák, František (referee)
Introduction: Graft versus host disease (GVHD) is a serious medical complication following allogeneic hematopoietic cell transplantation (allo HSCT). It causes immunodeficiency and several organ damage and decreases survival time at two years after a transplantation. A nutritional intervention should be applied just before the transplantation, because a nutritional status significantly influences the post-transplant complications. A risk of malnutrition or metabolic syndrome can be assessed by several markers. A combination of laboratory, anthropometric, biometric and physical data is suitable for this purpose. In addition, a subjective questionnaire regarding eating habits and physical activity of the patients can be used. Objectives: This thesis deals with the patients with chronic GVHD (cGVHD) following the allo HSCT. The objective was to describe a nutritional status of the patients, to find out in which way a long-term immunosuppressive treatment affects a body composition and to describe the eating habits and the physical activity of these patients. Methods: 31 patients with GVHD and 24 patients after allo HSCT without GVHD participated in the research. A body composition (using bioelectrical impedance) and selected laboratory parameters in patients were assessed. A subjective health...
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