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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Development of cardiovascular system function in patients with a functionally single ventricle
 Materna, Ondřej ; Janoušek, Jan (advisor) ; Klásková, Eva (referee) ; Urbanová, Zuzana (referee)
Development of cardiovascular system function in patients with a functionally single ventricle. Abstract Total cavopulmonary connection (TCPC) is the only possible surgical palliative procedure in patients with a functionally single ventricle. It consists of the stepwise anastomosis of both caval veins with pulmonary arteries, creating a unique situation of so-called Fontan circulation, where the separation of the pulmonary and systemic circuit is traded for chronically elevated systemic venous pressure and impaired cardiac output increase during exercise. We aimed to evaluate long-term results and development of exercise capacity in the population of patients with TCPC in the Czech Republic, possible predictors of their survival and functional outcome, as well as analysis of permanent cardiac resynchronization as one of the new treatment options for dysfunction of the single ventricle. We present a retrospective study of all consecutive patients in the Czech Republic identified in the nationwide single-centre institutional database and matched with the National Death Registry and Cardiovascular Intervention Registries. We proved that overall mean survival probability until composite end-point of death, TCPC take- down or indication for a heart transplant was 92.9 % at 20 years after the operation. TCPC...
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