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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
The late stage of mouse polyomavirus replication cycle: Preparation of methods for analysis of interactions of capsid protein, VP1, with nuclear cytoskeleton structures
 Maninová, Miloslava ; Forstová, Jitka (advisor) ; Němečková, Šárka (referee)
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Signaling mechanism in nuclear reorientation and its functional singnificance in cell migration.
 Maninová, Miloslava ; Vomastek, Tomáš (advisor) ; Hodný, Zdeněk (referee) ; Jaroš, Josef (referee)
The establishment of cellular polarity is first critical step of directional cell migration. The process of cellular polarization requires many signaling pathways that are differently regulated at the cell front and at the rear side and enables creation of typical asymmetrical profile of migrating cell. During the polarization cell forms the leading edge and trailing rear and relocalizes the intracellular organelles to such a position that is optimal for directional movement. In many migrating cells cell nucleus is usually located at the cell rear and microtubule organizing center localizes between the nucleus and the leading edge of the cell. This cellular arrangement is prerequisite for directional cell migration. We have shown that during cell polarization cell also reorients the nucleus to the direction of migration. The nuclear reorientation is temporally restricted rotation of the cell nucleus that aligns the longer nuclear axis with the axis of migration. Nuclear reorientation promotes the establishment of cellular polarity and facilitates the movement of the cell. The nuclear reorientation requires the physical linkage of the nucleus to cell cytoskeleton mediated by LINC (Linker of Nucleoskeleton and Cytoskeleton) complex. We have shown that LINC complex anchors the nucleus to actin stress...
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