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Densitometric determination of body composition in patients with chronic obstructive pulmonary disease
Malinová, Barbora ; Kovařík, Miroslav (advisor) ; Hronek, Miloslav (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Student: Barbora Malinová Supervisor of Diploma thesis: PharmDr. Miroslav Kovařík Ph.D. Title of diploma thesis: Densitometric determination of body composition in patients with chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in 2004 according to the WHO Global Burden of Disease Project and its morbidity and mortality worldwide is still increasing. Besides the lung function impairment, there are often described changes in body composition in COPD patients e.g. the skeletal muscle protein loss. The main aim of the study was determining the body composition by DEXA in patients diagnosed with COPD and comparing them with physiological values or studies dealing with this issue. On each patient was performed one examination, patients were coming after twelve-hour fasting. Average age was 66 ± 8 years. The amount of fat-free mass was not reduced. There was not therefore a loss of muscle tissue due to COPD. When evaluating total fat, we find that men have more fat than normal levels. This is also indicated by BMI that has been in the majority in the range of overweight and obesity. We did not confirm the link between COPD...
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Association of body composition parameters established using bioimpedance spectroscopy and predictors of morbidity and mortality in patients with COPD
Malinová, Barbora ; Kovařík, Miroslav (advisor) ; Hronek, Miloslav (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of Biological and Medical Science Candidate Mgr. Barbora Malinová Consultant PharmDr. Miroslav Kovařík, Ph.D. Title of Thesis Association of body composition parameters established using bioimpedance spectroscopy and predictors of morbidity and mortality in patients with COPD Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and its mortality and morbidity is still increasing. It manifests itself not only as reduced lung function, but there are present also changes in metabolism and body composition in these patients. Mostly it is skeletal muscle protein loss and malnutrition. The aim of this study was to evaluate the body composition determined using bioimpedance spectroscopy (BIS) and compare them with reference value or the studies dealing with this issue. We examined 7 women and 34 men in various stages of COPD. The total amount of fat mass was increased in 56 % of patients compared with reference values. The loss of skeletal muscle protein occurs only in 27 % of patients. The average body mass index was 28.2 ± 6.0 kg / cm2, which indicates overweight. Impedance values were significantly higher in women than in men in the range from 50 to 200 kHz and from 421 to 1000...
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Association of body composition parameters established using bioimpedance spectroscopy and predictors of morbidity and mortality in patients with COPD
Malinová, Barbora ; Kovařík, Miroslav (advisor) ; Hronek, Miloslav (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of Biological and Medical Science Candidate Mgr. Barbora Malinová Consultant PharmDr. Miroslav Kovařík, Ph.D. Title of Thesis Association of body composition parameters established using bioimpedance spectroscopy and predictors of morbidity and mortality in patients with COPD Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and its mortality and morbidity is still increasing. It manifests itself not only as reduced lung function, but there are present also changes in metabolism and body composition in these patients. Mostly it is skeletal muscle protein loss and malnutrition. The aim of this study was to evaluate the body composition determined using bioimpedance spectroscopy (BIS) and compare them with reference value or the studies dealing with this issue. We examined 7 women and 34 men in various stages of COPD. The total amount of fat mass was increased in 56 % of patients compared with reference values. The loss of skeletal muscle protein occurs only in 27 % of patients. The average body mass index was 28.2 ± 6.0 kg / cm2, which indicates overweight. Impedance values were significantly higher in women than in men in the range from 50 to 200 kHz and from 421 to 1000...
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Densitometric determination of body composition in patients with chronic obstructive pulmonary disease
Malinová, Barbora ; Kovařík, Miroslav (advisor) ; Hronek, Miloslav (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Student: Barbora Malinová Supervisor of Diploma thesis: PharmDr. Miroslav Kovařík Ph.D. Title of diploma thesis: Densitometric determination of body composition in patients with chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in 2004 according to the WHO Global Burden of Disease Project and its morbidity and mortality worldwide is still increasing. Besides the lung function impairment, there are often described changes in body composition in COPD patients e.g. the skeletal muscle protein loss. The main aim of the study was determining the body composition by DEXA in patients diagnosed with COPD and comparing them with physiological values or studies dealing with this issue. On each patient was performed one examination, patients were coming after twelve-hour fasting. Average age was 66 ± 8 years. The amount of fat-free mass was not reduced. There was not therefore a loss of muscle tissue due to COPD. When evaluating total fat, we find that men have more fat than normal levels. This is also indicated by BMI that has been in the majority in the range of overweight and obesity. We did not confirm the link between COPD...
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