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National Repository of Grey Literature

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Immune abnormalities and infectious complications in patients with diabetic foot and therapy of diabetic foot by off-loading Fejfarová, Vladimíra ; Jirkovská, Alexandra (advisor) ; Lacinová, Silvie (referee) ; Stárka, Luboslav (referee) The diabetic foot (DF) develops based on a complex of patophysiological processes which are presented in patients with diabetic complications. DF significantly increases a patient morbidity and mortality and markedly impairs the quality of life of these patients. The theme of the dissertation "immunological abnormalities and infection complications in patients with the DF and therapy of the DF by off-loading" was divided into 3 parts: - abnormalities of immune functions in connection with diabetes and its complications, especially with the DF - infectious complications of the DF - therapy of the DF by off-loading. Problems concerning the impairment of immune functions in connection with diabetes and the DF were resolved in 5 studies, infectious complications of the DF in 3 studies and the therapy of the DF by off-loading similarly in 3 studies. Abnormalities of immune functions in connection with diabetes and its complications, especially with the DF The first study deals with the effect of acute hyperglycemia and/or hyperinsulinemia on function of PMN cells in healthy subjects. The aim of this study was to assess the effect of short lasting acute metabolic changes on phagocytosis and the respiratory burst of PMN cells in healthy subjects in vivo. Acute hyperglycemia and/or hyperinsulinemia were... Detailed record

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1	Lacinová, Šárka

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