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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Enantioselective Synthesis of Chiral Cyclohexenones Using NHC Catalysis
 Lóška, Ladislav ; Veselý, Jan (advisor) ; Rýček, Lukáš (referee)
This work deals with the enantioselective synthesis of chiral cyclohexenones from substituted 4-nitroisoxazoles and α-bromo-α,β-unsaturated aldehydes using of N-heterocyclic carbenes (NHC) as organocatalysts. The work includes the preparation of commercially unavailable NHC-precursors and the synthesis of starting materials, substituted 4-nitroisoxazoles and α-bromo-α,β-unsaturated aldehydes. The second part of the work deals with the optimization of reaction conditions of the enantioselective synthesis of chiral cyclohexenones, proceeding via an azolium dienolate intermediate, and the detailed substrate scope screening.
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Synthesis of substituted 4-nitroisoxazoles
 Lóška, Ladislav ; Veselý, Jan (advisor) ; Matoušová, Eliška (referee)
This work deals with the preparation of a small library of enamines derived from isoxazole, compounds with the ability to inhibit a FOXO3-DNA interaction. The first part of the work is focused on the preparation of the key building block, (E)-N,N-dimethyl-2-(3- methyl-4-nitroisoxazole-5-yl)ethen-1-amine, and other starting materials. The second part is focused on the preparation 4-nitroisoxazole derivatives bearing methyl group at position 3 and a substituted vinyl moiety in position 5. Various secondary amines were used as substituents in order to modulate the polarity of the prepared 4-nitroisoxazole derivatives and to increase their solubility in water.
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