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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Synthesis and study of spectral and photophysical properties of a new water-soluble azaphthalocyanine bearing saccharide units on the periphery
 Krepsová, Veronika ; Nováková, Veronika (advisor) ; Švec, Jan (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department Department of Pharmaceutical Chemistry and Drug Control Candidate Mgr. Veronika Krepsová Supervisor PharmDr. Veronika Nováková, Ph.D. Title of Rigorous Thesis Synthesis and Study of Spectral and Photophysical Properties of a New Water-soluble Azaphthalocyanine Bearing Saccharide Units on the Periphery Azaphthalocyanines (AzaPc), the aza-analogues of phthalocyanines are macrocyclic compounds with large conjugated system giving them interesting spectral and photophysical properties useable in photodynamic therapy. An important condition for their use in this application is to provide solubility in an aqueous medium without losing their photodynamic activity. Water solubility can be achieved by the introduction of hydrophilic substituents on the periphery of the macrocycle. Hydrophilic substituents may be charged (anionic, cationic) or uncharged (e.g. hydroxyl-bearing). The aim of this thesis was to prepare and to study the properties of the water-soluble AzaPc bearing uncharged substituents on periphery, concretely saccharide unit, leading to AzaPc with 32 hydroxyl groups on the periphery. Zinc was chosen as the central metal because the zinc AzaPc are stable and responsible for good photophysical properties....
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Azaphthalocyanines substituted with one aminogroup - distance dependence on photoinduced electron transfer
 Krepsová, Veronika ; Zimčík, Petr (advisor) ; Opletalová, Veronika (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department: Department of Pharmaceutical Chemistry and Drug Control Candidate: Veronika Krepsova Supervisor: doc. PharmDr. Petr Zimcik, Ph.D. Title of Diploma Thesis: Azaphthalocyanines substituted with one aminogroup - distance dependence on photoinduced electron transfer Azaphthalocyanines (AzaPc), the aza-analogues of phthalocyanines are macrocyclic compounds with large conjugated system and mostly with high quantum yields of singlet oxygen and fluorescence. Intramolecular charge transfer (ICT) was discovered to proceed in AzaPc when alkylamino group is present on AzaPc periphery. ICT is responsible for quenching of excited states causing disappearance of singlet oxygen production and fluorescence emission. The aim of this thesis was to synthesize AzaPcs suitable for studying a similar process called photo-induced electron transfer (PET). In this process donor amino group is not in conjugation with AzaPc macrocycle, electron must "jump" over a distance leading to the quenching of excited states of molecules. In the first part of my work 5-chloro-6-methylpyrazine-2,3-dicarbonitrile was synthesized using nucleophilic substitution on 5-[2-(diethylamino)ethylsulfanyl]-6- methylpyrazine-2,3-dicarbonitrile (precursor A). The synthesis...
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