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Detection of early pathophysiological changes of breathing in children with chronic respiratory disease
Koucký, Václav ; Pohunek, Petr (advisor) ; Rybníček, Ondřej (referee) ; Chlumský, Jan (referee)
Detection of early pathophysiological changes of breathing in children with chronic respiratory disease MD. Vaclav Koucky - Ph.D. thesis Abstract Introduction: Currently, there are different methods for infant pulmonary function testing (iPFT) and morphological assessment of microscopic changes in endobronchial biopsy samples (EBB). In research setting, they allow detection of early pathophysiological changes of breathing in small children with chronic respiratory disease, respectively in risk of its development. Their clinical significance, however, is not fully acknowledged. The aim of this thesis is to evaluate the safety, feasibility and clinical significance of iPFT and EBB in infants younger than 2 years of age. In addition, the relationship between functional and morphological changes of respiratory tract and the function of peripheral chemoreceptors was studied in selected patients' subgroups. Methods: Fifty-five infants with cystic fibrosis (CF), 35 physician-confirmed recurrent wheezers (AB), 9 infants with congenital diaphragmatic hernia, 7 with interstitial lung disease (chILD) and 3 with primary ciliary dyskinesia (PCD) were enrolled. All infants underwent iPFT and relevant clinical history data were recorded. Based on patients' age, CF group was divided into CFmalí (< 6 months) and CFvelcí (>...
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Detection of early pathophysiological changes of breathing in children with chronic respiratory disease
Koucký, Václav ; Pohunek, Petr (advisor) ; Rybníček, Ondřej (referee) ; Chlumský, Jan (referee)
Detection of early pathophysiological changes of breathing in children with chronic respiratory disease MD. Vaclav Koucky - Ph.D. thesis Abstract Introduction: Currently, there are different methods for infant pulmonary function testing (iPFT) and morphological assessment of microscopic changes in endobronchial biopsy samples (EBB). In research setting, they allow detection of early pathophysiological changes of breathing in small children with chronic respiratory disease, respectively in risk of its development. Their clinical significance, however, is not fully acknowledged. The aim of this thesis is to evaluate the safety, feasibility and clinical significance of iPFT and EBB in infants younger than 2 years of age. In addition, the relationship between functional and morphological changes of respiratory tract and the function of peripheral chemoreceptors was studied in selected patients' subgroups. Methods: Fifty-five infants with cystic fibrosis (CF), 35 physician-confirmed recurrent wheezers (AB), 9 infants with congenital diaphragmatic hernia, 7 with interstitial lung disease (chILD) and 3 with primary ciliary dyskinesia (PCD) were enrolled. All infants underwent iPFT and relevant clinical history data were recorded. Based on patients' age, CF group was divided into CFmalí (< 6 months) and CFvelcí (>...
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Possible evaluations of respiratory parameters in physiotherapy using Multiple Breath Washout
Richtrová, Eva ; Zelenková, Jana (advisor) ; Koucký, Václav (referee)
The thesis presents a new method called Multiple Breath Washout (MBW) and its use in the assessment of breathing parameters in physiotherapy. The MBW evaluates respiratory parameters based on the washout of inert gas from the lungs and is applicable to all age categories. The theoretical part briefly summarizes the findings about the respiratory system and the types of functional lung examination, where spirometry is described and the larger part is devoted to less known method of Multiple Breath Washout. In the practical part, a preliminary study is carried out on two patients diagnosed with cystic fibrosis. The patients were examined and measured before and after a thirty minutes physiotherapy. The effect was measured by both methods - spirometry and Multiple Breath Washout. The aim of this thesis is to evaluate of short-term effect of physiotherapy on patients with chronic respiratory diseases.
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