|
|
Autoantibodies in women with infertility
Kopřivová, Helena ; Jílek, Petr (advisor) ; Drahošová, Marcela (referee)
Author: Helena Kopřivová Title: Autoantibodies in women with infertility Fieldof study: Medical laboratory technician, combined study form Aim of the thesis: In the thesis I have attempted to summarize the current knowledge on the relationship between the presence of autoimmune diseases or autoantibodies and infertility, with a focus on sterility. I compared these findings with the presence of autoantibodies and in relation to their occurrence in a group of 150 women who were referred to a detailed examination from a reproductive immunologist. Main findings: Infertility affects approximately 10 % of the world's population. For most of the women affected the cause of infertility is known. Approximately 10 % of women's infertility falls under the category of "unknown reasons". In a study group of 150 women it was necessary to exclude immunological problems that prevented pregnancy or led to repeated abortions. In our study group, 46 % of the infertile women were diagnosed with any of a variety of autoimmune diseases before visiting the center for assisted reproduction. In their cases, an early and proper diagnosis of autoimmune disease was a prerequisite to subsequent treatment techniques of assisted reproduction. The presence of positive antinuclear factor was very significant. Testing for...
|
|
| |
|
|
The dynamics of T regulatory lymphocytes generation during pregnancy
Kopřivová, Helena ; Krulová, Magdaléna (advisor) ; Frič, Jan (referee)
Regulatory T cells (Tregs) are CD 4+ T lymphocytes with regulatory and reparative properties. Tregs are functionally and differentially controlled by Foxp3 transcription factor, and they are considered a key factor inducing feto-maternal tolerance. Disruption of this unique type of time-limited immune tolerance leads to pregnancy complications including miscarriages, intrauterine growth retardation of the fetus, and premature delivery. Tregs' production and functional properties are influenced by the cytokine environment, especially by TGF-β1, IL-2, and retinoic acid. These pleiotropic factors are involved in the differentiation of tolerogenic populations of decidual cells. In the present work, a detailed immunophenotyping of Tregs was performed, and a determination of serum concentrations of TGF-β1 during physiological pregnancy was realized. The examined subpopulations of Tregs have shown different signs or markers of their functional and maturity properties. In some subpopulations, apparent changes in Treg counts were observed during pregnancy. Moreover, typical development was observed for TGF-β1 serum levels. The main goal of the current work was an examination of differences in Treg subpopulation counts in women with premature deliveries compared to females with full term births....
|
|
|
Autoantibodies in women with infertility
Kopřivová, Helena ; Jílek, Petr (advisor) ; Drahošová, Marcela (referee)
Author: Helena Kopřivová Title: Autoantibodies in women with infertility Fieldof study: Medical laboratory technician, combined study form Aim of the thesis: In the thesis I have attempted to summarize the current knowledge on the relationship between the presence of autoimmune diseases or autoantibodies and infertility, with a focus on sterility. I compared these findings with the presence of autoantibodies and in relation to their occurrence in a group of 150 women who were referred to a detailed examination from a reproductive immunologist. Main findings: Infertility affects approximately 10 % of the world's population. For most of the women affected the cause of infertility is known. Approximately 10 % of women's infertility falls under the category of "unknown reasons". In a study group of 150 women it was necessary to exclude immunological problems that prevented pregnancy or led to repeated abortions. In our study group, 46 % of the infertile women were diagnosed with any of a variety of autoimmune diseases before visiting the center for assisted reproduction. In their cases, an early and proper diagnosis of autoimmune disease was a prerequisite to subsequent treatment techniques of assisted reproduction. The presence of positive antinuclear factor was very significant. Testing for...
|
guest ::
RSS feed.