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S100 Proteins in Inflammatory Bowel Disease and Colorectal Neoplasia
Morávková, Paula ; Kohoutová, Darina (advisor) ; Ehrmann, Jiří (referee) ; Zavoral, Miroslav (referee)
S100 proteins in inflammatory bowel disease and colorectal neoplasia Inflammatory bowel disease and colorectal cancer represent a serious medical and socio- economic problem worldwide. Despite the progress in diagnostic of both diseases, there is no specific serum maker, which would allow to detect risk group of patients. Our paper focused on importance of serum S100 proteins in inflammatory bowel disease and colorectal neoplasia: (1) association of serum S100A4 with inflammatory bowel disease, ulcerative colitis and Crohn's disease, (2) association of serum S100A6, S100A8, S100A9 and S100A11 with colorectal neoplasia and (3) association of serum S100P with colorectal cancer. A total of 253 subject were enrolled: 40 healthy controls, 16 patients with ulcerative colitis, 93 patients with Crohn's disease, 20 patients with non-advanced colorectal adenoma, 20 patients with advanced colorectal adenoma and 62 patients with colorectal cancer. We confirmed significantly higher serum concentrations of S100A4 protein in patients with ulcerative colitis and Crohn's disease. In Crohn's disease, serum S100A4 was significantly higher in patients with colonic and ileocolonic involvement. We did not confirm association of serum S100A4 with fibrostenosing phenotype of Crohn's diseases and with perianal involvement. We...
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Large intestinal microbiota in inflammatory bowel disease and colorectal neoplasia
Kohoutová, Darina ; Bureš, Jan (advisor) ; Dítě, Petr (referee) ; Lata, Jan (referee)
Large intestinal microbiota in inflammatory bowel disease and colorectal neoplasia Sporadic colorectal cancer (CRC) and inflammatory bowel disease (IBD) represent an immense problem wordlwide. Precise definition of all the potential contributors to the pathogenesis of CRC and IBD remain a challenge. Large intestinal microbiota play an extremely important role. Investigation of serum anti-porin antibodies (aimed at porin C in the cell wall of E. coli) belonged to the objectives in the first part of our work. We have confirmed, that pacients with IBD and patients with CRC had increased levels of anti-porin antibodies. Bacteriocinogeny and investigation of E. coli genotypes belonged to the aims in the second part of our work. Bacteriocins are small proteins produced by bacteria of Enterobacteriaceae family and are characterised by its antibacterial, antineoplastic, probiotic and proapoptotic effect. We have confirmed higher bacteriocinogeny and presence of more virulent strains of E. coli in patients with advanced colorectal adenoma and colorectal carcinoma. All these results confirm contribution of large intestinal microbiota to the development of colorectal pathologies.
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