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The role of microtubule dynamics in cancer metastasis
Klubíčková, Natálie ; Čermák, Vladimír (advisor) ; Dostál, Vojtěch (referee)
Cancer is one of the main mortality causes worldwide, and the majority of cancer-related deaths occur due to metastasis. During the metastatic cascade, cancer cells acquire a specific and highly plastic phenotype that enables them to detach from the primary tumor and invade the surrounding tissue, migrate avidly, evade host immunity, survive in different hostile environments and colonize secondary sites to establish metastases. Changes in microtubule dynamics together with other parts of cell cytoskeleton regulation are crucial for cancer cells undergoing the metastatic process. In the first part of this thesis, I review critical moments of the metastatic cascade in relation to microtubule-associated signaling, while detailed information on important microtubule-associated proteins and their role in metastasis is provided in the second section. Keywords: Metastasis, microtubule, cancer, migration, microtubule-associated proteins.
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